Document Detail

Carnitine deficiency in pregnancy.
MedLine Citation:
PMID:  17666635     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Carnitine deficiency is a potential cause of metabolic crisis during periods of high energy demand or stress. Affected individuals have very low carnitine levels in blood, decreased carnitine transport in fibroblasts, and commonly have mutations in the OCTN2 gene. CASE: We report management through pregnancy and delivery of a patient with carnitine deficiency who had reduced carnitine transport in fibroblasts, but no mutations in the OCTN2 gene. CONCLUSION: Carnitine deficiency can be treated with exogenous carnitine in select patients during pregnancy. This is especially helpful, because carnitine levels decrease during pregnancy in normal individuals, and neonates are dependent on exogenous carnitine.
Christopher T Donnelly; Afshan B Hameed; Jose E Abdenur; Deborah A Wing
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  110     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-06     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  480-2     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of California, Irvine, California 92868, USA.
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MeSH Terms
Carnitine / deficiency*,  metabolism,  therapeutic use*
Cesarean Section
Fibroblasts / metabolism*
Pregnancy Complications / drug therapy*,  genetics
Pregnancy Outcome
Vitamin B Complex / metabolism,  therapeutic use
Vitamin B Deficiency / complications*,  drug therapy*,  genetics
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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