| Carnitine and cardiac interstitium. | |
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MedLine Citation:
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PMID: 7919051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An important part of (acyl)carnitine may be stored in interstitial spaces and the external surface of adjacent cells. A high concentration of carnitine in the direct vicinity of cells may enhance the synthesis and export of long-chain acylcarnitine. Long-chain acylcoenzyme A, from which long-chain acyl carnitine is formed, cannot penetrate intact cell membranes. During hypoperfusion or ischemia, when long-chain acylcoenzyme A accumulates due to hampered fatty acid oxidation, there is an increased formation of long-chain acyl carnitine which diffuses into the interstitium and adjacent vascular endothelial cells. Due to its lipophilic nature and net positive charge (limitation of carboxyl-group dissociation in ischemic acidosis), long-chain acyl carnitine may decrease the affinity of Ca2+ to the cell surface and prevent Ca2+ overload of cells. The advantage of carnitine over many other cationic amphiphiles in the protection of areas of ischemia is that long-chain acyl carnitine is formed and stored only in ischemic areas. |
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Authors:
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W C Hülsmann; A Peschechera; E Arrigoni-Martelli |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardioscience Volume: 5 ISSN: 1015-5007 ISO Abbreviation: Cardioscience Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-11-07 Completed Date: 1994-11-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9014943 Medline TA: Cardioscience Country: ITALY |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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Thoraxcenter, Erasmus University, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channels / metabolism Carnitine / biosynthesis, metabolism* Heart / physiology Humans Myocardial Ischemia / physiopathology* Myocardium / cytology, metabolism* Oxygen / metabolism Rats |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 541-15-1/Carnitine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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