| Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats. | |
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MedLine Citation:
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PMID: 22085273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased cytokine expression contributes to the pathogenesis of cancer anorexia?cachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested the effects of L-propionylcarnitine (PC group) or saline (C group) on food intake (FI), body composition, and inflammatory status of MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned to daily i.p. injection of L-propionylcarnitine (250 mg/kgBW/d; n = 8) or saline (equal volume; n = 8). FI and fat-free mass wasting improved in PC rats only (p < .01 vs. controls). Cytokines? levels decreased in PC rats vs. controls (p < .02). Results suggest that carnitine may ameliorate cancer anorexia?cachexia, via reduction of the inflammatory status. |
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Authors:
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Alessandro Laviano; Alessio Molfino; Marilia Seelaender; Teresa Frascaria; Giuseppe Bertini; Cesarina Ramaccini; Maria Rosa Bollea; Gennaro Citro; Filippo Rossi Fanelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer investigation Volume: 29 ISSN: 1532-4192 ISO Abbreviation: Cancer Invest. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-17 Completed Date: 2011-12-29 Revised Date: 2012-03-12 |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: England |
Other Details:
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Languages: eng Pagination: 696-700 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine , Sapienza University of Rome, Italy. alessandro.laviano@uniroma1.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anorexia / drug therapy Body Composition / drug effects* Cachexia / drug therapy Carnitine / analogs & derivatives*, pharmacology Cytokines / blood* Eating / drug effects* Male Neoplasms, Experimental / metabolism* Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 17298-37-2/propionylcarnitine; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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