| Cariporide for pharmacologic defibrillation after prolonged cardiac arrest. | |
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MedLine Citation:
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PMID: 12232565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We hypothesized that cariporide, a sodium-hydrogen exchange inhibitor, would be as cardioprotective during the global myocardial ischemia of prolonged cardiac arrest as it is in settings of coronary occlusion. METHODS AND RESULTS: Fifteen Sprague-Dawley rats were randomized to receive bolus injections of cariporide or placebo in a dose of 3 mgxkg(-1) into the right atrium either 5 minutes before, or at 8 minutes after, onset of ventricular fibrillation. Ventricular fibrillation was electrically induced and untreated for 8 minutes. Precordial compression, together with mechanical ventilation, was then started and continued for an interval of 8 minutes prior to attempted resuscitation. All but one placebo-treated animal were successfully resuscitated. Spontaneous defibrillation with restoration of circulation was observed in both cariporide-pretreatment and post-treatment groups but in none of the placebo-treated animals. Postresuscitation cardiac index, end-tidal CO(2), mean aortic pressure, left ventricular systolic pressure, left ventricular end-diastolic pressure, and left ventricular contractile and lusitropic functions (dP/dt(40), and -dP/dt) were significantly less impaired after cariporide, especially in the pretreated group, compared to electrically defibrillated controls. Postresuscitation ventricular premature beats were significantly reduced after cariporide. The duration of post-resuscitation survival was significantly increased in animals pretreated with cariporide. CONCLUSIONS: Cariporide, when administered prior to and during cardiac arrest, improved both the success of resuscitation and postresuscitation myocardial function. |
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Authors:
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Shue-ren Wann; Max Harry Weil; Shijie Sun; Wanchun Tang; Ting Yu |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cardiovascular pharmacology and therapeutics Volume: 7 ISSN: 1074-2484 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-09-16 Completed Date: 2003-03-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 161-9 Citation Subset: IM |
Affiliation:
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Institute of Critical Care Medicine, Palm Springs, CA 92264, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electric Countershock / methods Guanidines / therapeutic use* Heart Arrest / drug therapy*, physiopathology Male Rats Rats, Sprague-Dawley Sulfones / therapeutic use* Ventricular Fibrillation / drug therapy*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL-54322/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Guanidines; 0/Sulfones; 0/cariporide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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