| Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity. | |
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MedLine Citation:
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PMID: 19853351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: VF was electrically induced in 20 male pigs and left untreated for 6 min after which CPR was initiated and continued for 8 min before attempting defibrillation. Pigs were randomized to receive 3-mg/kg cariporide (n=10) or 0.9%-NaCl (n=10) before chest compression. RESULTS: Seven of 10 pigs in each group were successfully resuscitated and survived 2h. Cariporide ameliorated post-resuscitation ventricular ectopic activity such that fewer singlets (5+/-5 vs. 26+/-21; p<0.05) and fewer bigemini (1+/-3 vs. 33+/-25; p<0.05) were observed during the initial 5 min post-resuscitation. Additionally, cariporide-treated pigs did not require additional post-resuscitation shocks for ventricular tachycardia or recurrent VF (0.0+/-0.0 vs. 5.3+/-7.8 shocks; p=0.073). During the initial 60 min cariporide-treated pigs had higher, cardiac index (6.1+/-0.7 vs. 4.4+/-1.1L/min/m(2); p<0.01), left ventricular stroke work index (45+/-9 vs. 36+/-10 gmm/beat/m(2); p<0.05), and numerically higher mean aortic pressure (104+/-11 vs. 91+/-12 mmHg; p=0.054). CONCLUSION: Cariporide administered at the start of chest compression may help restore electrically and mechanically stable circulation after resuscitation from cardiac arrest. |
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Authors:
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Iyad M Ayoub; Julieta Kolarova; Raúl J Gazmuri |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-10-22 |
Journal Detail:
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Title: Resuscitation Volume: 81 ISSN: 1873-1570 ISO Abbreviation: Resuscitation Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-05-04 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 106-10 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Resuscitation Institute at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Anti-Arrhythmia Agents / pharmacology* Cardiopulmonary Resuscitation* Guanidines / pharmacology* Heart Massage Male Statistics, Nonparametric Sulfones / pharmacology* Survival Rate Swine Ventricular Fibrillation / drug therapy*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL071728-01/HL/NHLBI NIH HHS; R01 HL71728-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Guanidines; 0/Sulfones; 0/cariporide |
| Comments/Corrections | |
Comment In:
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Resuscitation. 2010 Nov;81(11):1584; author reply 1584-5
[PMID:
20638771
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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