Document Detail


Carica papaya lipase (CPL): an emerging and versatile biocatalyst.
MedLine Citation:
PMID:  16716557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, the Carica papaya lipase (CPL) is attracting more and more interest. This hydrolase, being tightly bonded to the water-insoluble fraction of crude papain, is thus considered as a "naturally immobilized" biocatalyst. To date, several CPL applications have already been described: (i) fats and oils modification, derived from the sn-3 selectivity of CPL as well as from its preference for short-chain fatty acids; (ii) esterification and inter-esterification reactions in organic media, accepting a wide range of acids and alcohols as substrates; (iii) more recently, the asymmetric resolution of different non-steroidal anti-inflammatory drugs (NSAIDs), 2-(chlorophenoxy)propionic acids, and non-natural amino acids. Taking into account the novelty and the current interest of the topic, this review aims to highlight the origin, features, and applications of the C. papaya lipase, with the objective to prompt research groups to further investigate the spectra of applications that this emerging and versatile CPL could have in the future.
Authors:
Pablo Domínguez de María; José V Sinisterra; Shau-Wei Tsai; Andrés R Alcántara
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-18
Journal Detail:
Title:  Biotechnology advances     Volume:  24     ISSN:  0734-9750     ISO Abbreviation:  Biotechnol. Adv.     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8403708     Medline TA:  Biotechnol Adv     Country:  England    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  IM    
Affiliation:
Biotransformations Group, Organic and Pharmaceutical Chemistry Department, Faculty of Pharmacy, Complutense University, Pza. Ramón y Cajal s/n. E-28040, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Alcohols / chemistry
Carica / enzymology*
Catalysis
Lipase / metabolism*
Lipids / chemistry
Stereoisomerism
Chemical
Reg. No./Substance:
0/Alcohols; 0/Lipids; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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