Document Detail


Carica papaya (Paw-Paw) unripe fruit may be beneficial in ulcer.
MedLine Citation:
PMID:  20041780     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anti-ulcer potentials of aqueous (AE) and methanol (ME) extracts of whole unripe Carica papaya fruit were evaluated using ethanol- and indomethacin-induced gastric ulcer models in rats. The effect of the extracts on small intestinal propulsion was also investigated. The extracts significantly reduced the ulcer index in both experimental models (P < .05) compared to the control group. ME showed a better protection against indomethacin-induced ulcers, whereas AE was more effective against ethanol-induced gastric ulcers. The extracts also significantly (P < .05) inhibited intestinal motility, with ME showing greater activity. Oral administration of AE and ME up to 5,000 mg/kg did not produce lethality or signs of acute toxicity in mice after 24 hours. The extracts of unripe C. papaya contain terpenoids, alkaloids, flavonoids, carbohydrates, glycosides, saponins, and steroids. The cytoprotective and antimotility properties of the extracts may account for the anti-ulcer property of the unripe fruit.
Authors:
A C Ezike; P A Akah; C O Okoli; N A Ezeuchenne; S Ezeugwu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal food     Volume:  12     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-31     Completed Date:  2010-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1268-73     Citation Subset:  IM    
Affiliation:
Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. adaobiezike@yahoo.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Carica / chemistry*
Disease Models, Animal
Female
Fruit / chemistry*
Humans
Male
Mice
Plant Extracts / administration & dosage*,  adverse effects,  chemistry
Random Allocation
Rats
Stomach Ulcer / drug therapy*
Chemical
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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