Document Detail

Cardiovascular and thrombosis pathology associated with cocaine use.
MedLine Citation:
PMID:  8294312     Owner:  NLM     Status:  MEDLINE    
After decades of focus on the effects of cocaine abuse on the central nervous system (CNS), the cardiovascular toxicity of cocaine is just beginning to be appreciated. The most common cardiovascular pathologies associated with cocaine use include: cardiomyopathy, left ventricular dysfunction, myocarditis, arrhythmia, hypertension, myocardial infarction, stroke, arterial thrombosis, deep vein thrombosis, and gastrointestinal, renal, and skeletal muscle ischemia. This article reviews the above pathologies with speculations on the mechanisms by which cocaine produces cardiovascular tissue damage.
A L Killam
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Hematology/oncology clinics of North America     Volume:  7     ISSN:  0889-8588     ISO Abbreviation:  Hematol. Oncol. Clin. North Am.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-28     Completed Date:  1994-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709473     Medline TA:  Hematol Oncol Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1143-51     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Michigan State University, East Lansing.
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MeSH Terms
Cardiovascular Diseases / chemically induced*
Cocaine / adverse effects*
Thrombosis / etiology*
Reg. No./Substance:

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