Document Detail

Cardiovascular studies during induction with minaxolone.
MedLine Citation:
PMID:  547658     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of induction of anesthesia with minaxolone, a new water soluble steroid agent, have been studied in 12 normotensive patients and 5 patients with treated hypertension. The arterial pressure, heart rate and ECG were continuously recorded before and during induction of anesthesia with Minaxolone 0.5 mg kg-1. Cardiac output measurements were made in the awake patient, at 3 minutes after the induction of anesthesia and 2 minutes after an increment of the drug. In both groups of patients, induction of anesthesia led to a decrease in systolic arterial pressure and a smaller decrease in diastolic arterial pressures. This was coupled with an increase in the heart rate. The decrease in cardiac output was similar in both the normal and treated hypertensive patients. Administration of an increment of minaxolone (0.1 mg kg-1) did not produce further significant changes in the cardiovascular variables. The results of this study show that the changes in hemodynamic variables with minaxolone are comparable with those seen following induction of anesthesia with other intravenous agents, with the one difference in that there was only minimal change in the diastolic arterial pressure.
J W Sear; C Prys-Roberts; J Dye
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Belgica     Volume:  30 Suppl     ISSN:  0001-5164     ISO Abbreviation:  Acta Anaesthesiol Belg     Publication Date:  1979  
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0421022     Medline TA:  Acta Anaesthesiol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  161-8     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Intravenous*
Anesthetics / pharmacology*
Blood Gas Analysis
Blood Pressure / drug effects
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / physiopathology
Pregnanes / pharmacology*
Pregnanolone / analogs & derivatives,  pharmacology*
Time Factors
Vascular Resistance / drug effects
Reg. No./Substance:
0/Anesthetics; 0/Pregnanes; 128-20-1/Pregnanolone; 62571-87-3/minaxolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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