| Cardiovascular stability with rapid intravenous infusion of ondansetron. | |
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MedLine Citation:
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PMID: 8513525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute cardiovascular effects of rapid iv administration of the antiemetic ondansetron, a selective serotonin (5-HT3) receptor antagonist were determined in a randomized, blinded, placebo-controlled study. Measurements of heart rate, blood pressure, oxygen saturation and respiratory rate were made preoperatively over a five-minute period which followed a two-minute infusion of the medication. Intraoperative and postoperative data were not collected. None of the variables recorded changed significantly during the infusion or in the observation period which followed. Within the limitations of this study, we detected no cardiovascular change in the five minutes between the end of the drug infusion and the induction of anaesthesia. |
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Authors:
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J S Heyman; M L Young; R J Bagshaw; W J Levy; R T Geer; S J Aukburg; A F Joslyn; T J Conahan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 40 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-16 Completed Date: 1993-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: CANADA |
Other Details:
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Languages: eng Pagination: 448-52 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, University of Pennsylvania, Philadelphia 19104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General Blood Pressure / drug effects* Diastole Female Heart Rate / drug effects* Humans Injections, Intravenous Middle Aged Ondansetron / administration & dosage, therapeutic use* Oxygen / blood* Placebos Premedication Respiration / drug effects* Single-Blind Method Systole Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 7782-44-7/Oxygen; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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