| Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged. | |
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MedLine Citation:
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PMID: 429744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a study to determine the nature and frequency of cardiac side effects during long-term administration of tricyclic antidepressant drugs in usual dosages in the aged, 32 geriatric patients were followed for an average of 36.6 weeks. Ten of them received amitriptyline in a daily dosage of 20-75 mg for 53 weeks (average); in 2, electrocardiographic side effects developed, viz, inversion of the T waves or evidence of acute coronary insufficiency. Imipramine was administered to 21 patients in a daily dosage of 20-100 mg (average, 66 mg) over a period of 40 weeks; in 3 instances major side effects developed--intermittent left bundle-branch block, acute coronary insufficiency with node dysfunction, or T-wave inversion with sinus tachycardia; in 1 instance there was a minor side effect, viz, tachycardia only. In 1 patient, acute myocardial infarction developed after two 10-mg doses of nortriptyline. Five of the 7 patients with cardiac side effects had prior organic heart disease. It was concluded that the incidence of cardiac side effects in aged persons given tricyclic antidepressant drugs in the usual therapeutic dosages for a prolonged period is great enough to warrant frequent careful monitoring of cardiac status during therapy. |
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Authors:
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M Rodstein; L S Oei |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 27 ISSN: 0002-8614 ISO Abbreviation: J Am Geriatr Soc Publication Date: 1979 May |
Date Detail:
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Created Date: 1979-06-29 Completed Date: 1979-06-29 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 231-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amitriptyline / adverse effects Antidepressive Agents, Tricyclic / adverse effects* Arrhythmias, Cardiac / chemically induced Cardiovascular System / drug effects* Electrocardiography Female Heart Block / chemically induced Heart Failure / chemically induced Humans Imipramine / adverse effects Male Myocardial Infarction / chemically induced Nortriptyline / adverse effects Thiothixene / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 50-48-6/Amitriptyline; 50-49-7/Imipramine; 5591-45-7/Thiothixene; 72-69-5/Nortriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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