| Cardiovascular side effects of atomoxetine and its interactions with inhibitors of the cytochrome p450 system. | |
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MedLine Citation:
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PMID: 21765848 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor (SNRI), one of the first medications in the nonstimulant class of medications that has been approved by the FDA for the treatment of ADHD. Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. Cardiovascular side effects are less commonly reported. The increase in the noradrenergic tone may explain some of the side effects noted with the use of this medication. Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug. |
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Authors:
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Pashtoon Murtaza Kasi; Rawad Mounzer; George H Gleeson |
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Publication Detail:
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Type: Journal Article Date: 2011-07-03 |
Journal Detail:
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Title: Case reports in medicine Volume: 2011 ISSN: 1687-9635 ISO Abbreviation: Case Report Med Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101512910 Medline TA: Case Report Med Country: United States |
Other Details:
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Languages: eng Pagination: 952584 Citation Subset: - |
Affiliation:
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PGY1, International Scholars Program, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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