| Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine. | |
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MedLine Citation:
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PMID: 11134656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Almotriptan is a new 5-HT(1B/1D) receptor agonist effective for treating acute migraine attacks with or without aura. As 3-5% of patients treated with sumatriptan experience chest symptoms thought to be of cardiac origin, we investigated the cardiovascular safety profile of almotriptan in comparison with that of sumatriptan in six animal models. Almotriptan did not modify blood pressure or heart rate in conscious telemetered normotensive Wistar rats (p.o.), in anaesthetised beagle dogs (i.v.), or in conscious beagle dogs (i.v.), and only produced transient increases when administered (s.c.) to telemetered cynomolgus monkeys. Almotriptan did not consistently affect the duration of the electrocardiogram (ECG) intervals in anaesthetised beagle dogs even when the drug was administered into the coronary artery, nor was ECG morphology altered in telemetered cynomolgus monkeys. In contrast, sumatriptan i.v. consistently increased mean blood pressure and heart rate in conscious beagle dogs. Finally, almotriptan did not modify coronary blood flow at a dose of up to 0.3 mg/kg i.v. in conscious beagle dogs. Thus, almotriptan has a favourable cardiovascular safety profile. |
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Authors:
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J Gras; I Cardelús; J Llenas; J M Palacios |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 410 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-31 Completed Date: 2001-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 53-9 Citation Subset: IM |
Affiliation:
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Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-, Barcelona, Spain. jgras@almirallprodesfarma.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiovascular System / drug effects* Cats Coronary Circulation / drug effects Coronary Vessels / drug effects Dogs Electrocardiography Female Guinea Pigs Heart Rate / drug effects Indoles / pharmacology* Injections, Subcutaneous Macaca fascicularis Male Migraine Disorders / drug therapy* Rats Rats, Wistar Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin / metabolism Safety Serotonin Agonists / pharmacology* Sumatriptan / pharmacology Tryptamines |
| Chemical | |
Reg. No./Substance:
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0/Indoles; 0/Receptor, Serotonin, 5-HT1B; 0/Receptor, Serotonin, 5-HT1D; 0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Tryptamines; 103628-46-2/Sumatriptan; 154323-57-6/almotriptan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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