Document Detail

Cardiovascular risk: the safety of local anesthesia, vasoconstrictors, and sedation in heart disease.
MedLine Citation:
PMID:  11692352     Owner:  NLM     Status:  MEDLINE    
As part of a large pragmatic study, the authors investigated heart rate, blood pressure, dysrhythmic and ischemic responses to lidocaine 2% with a combination vasoconstrictor (noradrenaline 1:50,000 and vasopressin 0.25 IU/mL), and midazolam sedation in a medically compromised population. There were anesthesia-induced physiological changes to both hemodynamics and the electrocardiogram. The use of midazolam significantly ameliorated the sympathoadrenal response to stress, and the greatest hemodynamic and electrocardiographic changes were observed during surgery.
R J Middlehurst; A Gibbs; G Walton
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia progress     Volume:  46     ISSN:  0003-3006     ISO Abbreviation:  Anesth Prog     Publication Date:  1999  
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0043533     Medline TA:  Anesth Prog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  118-23     Citation Subset:  D    
University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH, England.
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MeSH Terms
Anesthesia, Dental
Anesthetics, Local / administration & dosage*
Arrhythmias, Cardiac / physiopathology
Blood Pressure / drug effects*
Conscious Sedation
Electrocardiography / drug effects*
Epinephrine / therapeutic use
Follow-Up Studies
Heart Diseases / physiopathology*
Heart Rate / drug effects*
Hemodynamics / drug effects
Hypnotics and Sedatives / therapeutic use*
Lidocaine / administration & dosage
Midazolam / therapeutic use
Middle Aged
Myocardial Ischemia / physiopathology
Oral Surgical Procedures*
Single-Blind Method
Statistics as Topic
Statistics, Nonparametric
Stress, Physiological / physiopathology
Vasoconstrictor Agents / therapeutic use*
Vasopressins / therapeutic use
Reg. No./Substance:
0/Anesthetics, Local; 0/Hypnotics and Sedatives; 0/Vasoconstrictor Agents; 11000-17-2/Vasopressins; 137-58-6/Lidocaine; 51-43-4/Epinephrine; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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