Document Detail


Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients.
MedLine Citation:
PMID:  16509055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cardiovascular disease (CVD) is the major cause of mortality and morbidity of hemodialysis (HD) and peritoneal dialysis (CAPD) patients. We aimed to investigate the cardiovascular risk factors and their correlation with CVD in groups of HD and CAPD patients. METHODS: Thirty HD patients, 30 CAPD patients and 30 healthy controls were included in the study. Apolipoprotein A-l (apo A-l), apolipoprotein B (apo B), apolipoprotein(a) [Lp(a)] and high-sensitivity CRP (hs-CRP) were measured with a Beckman Coulter nephelometer, and homocysteine (Hcy) was determined with an Agilent HPLC analyzer. Lipid profile was determined with a Synchron LX 20 Pro analyzer. RESULTS: Hcy levels were 41.9+/-19.4, 41.8+/-38.5 and 9.3+/-3.5 micromol/L; Lp(a) levels were 325+/-315, 431+/-367 and 130+/-97 mg/L; hs-CRP levels were 3.78+/-3.21, 4.34+/-3.39 and 2.07+/-1.67 mg/L; apo A1/apo B ratios were 1.46+/-0.6, 1.36+/-0.5 and 1.80+/-0.59; total cholesterol levels were 3.56+/-0.7, 4.84+/-1.1 and 4.39+/-0.5 mmol/L; triglycerides were 1.44+/-0.5, 1.60+/-0.8 and 0.85+/-0.5 mmol/L in the HD, CAPD and control groups, respectively. CONCLUSION: HD and CAPD patients had higher Hcy, hs-CRP and Lp(a) levels and lower apo A/B ratios than controls. There was no significant difference between the HD and CAPD groups. Hypertension, age and hs-CRP showed a positive correlation with CVD.
Authors:
F M Yilmaz; G Yilmaz; M Duranay; H Parpucu; M Senes; N Tekeli; D Y?cel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  65     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2005  
Date Detail:
Created Date:  2006-03-01     Completed Date:  2006-03-07     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  739-45     Citation Subset:  IM    
Affiliation:
Clinical Biochemistry Laboratory, Ministry of Health, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging
Apolipoproteins A / blood
Apolipoproteins B / blood
C-Reactive Protein / analysis
Cardiovascular Diseases / blood*,  complications*,  etiology,  mortality
Case-Control Studies
Female
Homocysteine / blood,  metabolism
Humans
Hypertension / blood,  complications
Kidney Diseases / blood,  complications*
Lipoprotein(a) / blood
Male
Peritoneal Dialysis* / adverse effects
Renal Dialysis* / adverse effects
Risk Factors
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Apolipoproteins B; 0/Lipoprotein(a); 454-28-4/Homocysteine; 9007-41-4/C-Reactive Protein

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