Document Detail


Cardiovascular risk factors as predictors of mortality in type II diabetic patients.
MedLine Citation:
PMID:  10081124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mortality among diabetic patients is high and attempts have been made to find clinical markers which would help to identify patients at risk. MAIN PURPOSE: The purpose of this study was to assess whether cardiovascular risk factors like previous myocardial infarction, left ventricular dysfunction, hypertension, renal insufficiency, and 24-hour mean or minimum heart rate, significantly contribute to the mortality in this group of patients. METHODS: 45 male patients with type II diabetes mellitus were studied by ambulatory electrocardiography to obtain the information about the 24-hour mean and minimum heart rates; records from baseline hospitalization were reviewed for clinical variables. After 55 months mortality data were retrieved. Cox's proportional hazards regression model was used to study the effect of clinical variables on mortality in multivariate analysis. RESULTS: All-cause mortality was 38%. The groups of survivors and nonsurvivors differed significantly in terms of age, the presence of left ventricular dysfunction and renal insufficiency. No significant difference in 24-hour mean or minimum heart rate was registered. In the Cox's model, the presence of left ventricular dysfunction, renal insufficiency and age significantly and independently predicted mortality. CONCLUSION: The present study, showed that left ventricular dysfunction and renal insufficiency were related to the all-cause mortality of type II diabetic patients independently of age, after 55 months of follow-up. Prognostic significance of 24-hour mean or minimum heart rate has not been proven.
Authors:
T Mudríková; J Gmitrov; I Tkác; J Gonsorcík; M Szakács
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  111     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-08     Completed Date:  1999-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Affiliation:
Clinic of Internal Medicine IV, Louis Pasteur University Hospital, Kosice, Slovakia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cardiovascular Diseases / mortality*
Cause of Death*
Diabetes Mellitus, Type 2 / mortality*
Electrocardiography, Ambulatory
Follow-Up Studies
Humans
Male
Middle Aged
Models, Statistical
Regression Analysis
Risk Factors
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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