Document Detail

Cardiovascular risk factors and antihypertensive therapy.
MedLine Citation:
PMID:  2905869     Owner:  NLM     Status:  MEDLINE    
Reduction of elevated blood pressure is effective in reducing morbidity and mortality from cardiovascular disease in general. Striking decreases in stroke, congestive heart failure, and renal impairment have been observed when blood pressure is reduced. However, the ability of traditional, diuretic-first, stepped-care therapeutic algorithms to reduce the occurrence of myocardial infarction or angina has been exceedingly difficult to demonstrate. An increased frequency of sudden death among hypertensive men with electrocardiographic abnormalities has been observed in some diuretic-based treatment trials. The failure of conventional therapy to reduce coronary artery disease and death has forced a re-appraisal of antihypertensive treatment. The risk factors for coronary disease are reviewed in detail with an emphasis on the impact of various classes of antihypertensive drugs on these factors. The emergence of effective antihypertensive agents that lower blood pressure without adversely affecting cardiovascular risk factors provides a new opportunity to further extend the benefit of treatment by reducing such risk.
M H Weinberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  84     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1989-03-02     Completed Date:  1989-03-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  AIM; IM    
Hypertension Research Center, Indiana University School of Medicine, Indianapolis 46223.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Cardiovascular Diseases / etiology*,  physiopathology
Diabetes Complications
Hypertension / blood,  complications,  drug therapy*,  physiopathology
Lipids / blood
Risk Factors
Sodium Chloride Symporter Inhibitors / therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzothiadiazines; 0/Diuretics; 0/Lipids; 0/Sodium Chloride Symporter Inhibitors

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