Document Detail

Cardiovascular risk factor profile in subjects with familial predisposition to myocardial infarction in Denmark.
MedLine Citation:
PMID:  9229055     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To identify possible modifiable mediators of familial predisposition to myocardial infarction (MI) by assessing the risk factor profile in individuals without MI in relation to parental occurrence of MI. DESIGN AND METHODS: Cross sectional survey of the general population. The odds of an adverse cardiovascular risk factor profile in subjects reporting parental occurrence of MI versus subjects not reporting parental occurrence were estimated by logistic regression models. SETTING: The Copenhagen Centre for Prospective Population Studies, where subjects investigated in three Danish prospective population studies are integrated. PARTICIPANTS: Subjects were 9306 females and 11,091 males aged 20-75 years with no history of MI. A total of 1370 subjects reported maternal MI and 2583 reported paternal MI. MAIN RESULTS: Increased systolic and diastolic blood pressure, increased cholesterol level, low ratio between high density lipoprotein (HDL) and total cholesterol (TC), and heavy smoking, were more frequent in subjects with parental occurrence of MI than in controls irrespective of sex and age of the subjects. Maternal MI was more predictive for increased cholesterol and decreased HDL/ TC ratio than paternal MI, and the risk of an increased cholesterol level was higher in subjects aged 20-39 years than in older subjects. No differences in body mass index, triglycerides, and physical inactivity were observed. CONCLUSIONS: Subjects free of previous MI who reported a parental occurrence of MI had an adverse cardiovascular risk factor profile regarding systolic and diastolic blood pressure, total cholesterol, the ratio between HDL and total cholesterol, and smoking. Thus, these modifiable risk factors may be mediators of the familial predisposition to MI.
M Hippe; J Vestbo; A M Bjerg; K Borch-Johnsen; M Appleyard; H O Hein; P K Andersen; G Jensen; T I Sørensen
Related Documents :
10090535 - Reflex testing i: algorithm for lipid and lipoprotein measurement in coronary heart dis...
1466315 - Epidemiology of triglycerides: a view from framingham.
19187075 - Lipid biomarkers, hormone therapy and the risk of venous thromboembolism in women.
11590455 - Blood lipids and body fat in bahraini women.
905465 - The prevalence of minor psychiatric morbidity in the community.
8633735 - Chronic gynecological conditions reported by us women: findings from the national healt...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of epidemiology and community health     Volume:  51     ISSN:  0143-005X     ISO Abbreviation:  J Epidemiol Community Health     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-14     Completed Date:  1997-08-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7909766     Medline TA:  J Epidemiol Community Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  266-71     Citation Subset:  IM    
Copenhagen Centre for Prospective Population Studies, Institute of Preventive Medicine, Copenhagen University Hospital, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Blood Pressure
Body Mass Index
Cholesterol / blood
Cholesterol, HDL / blood
Cohort Studies
Cross-Sectional Studies
Logistic Models
Middle Aged
Myocardial Infarction / genetics*,  physiopathology
Odds Ratio
Prospective Studies
Risk Factors
Triglycerides / analysis
Reg. No./Substance:
0/Cholesterol, HDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Weight gain during the first year of life in relation to maternal smoking and breast feeding in Norw...
Next Document:  Political changes and trends in cardiovascular risk factors in the Czech Republic, 1985-92.