Document Detail


Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry.
MedLine Citation:
PMID:  19054514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates. METHODS: The REACH Registry recruited >68000 outpatients aged >or=45 years with established atherothrombotic disease or >or=3 RFs for atherothrombosis. The predictors of RF control that were evaluated included: (1) patient demographics, (2) mode of PAD diagnosis, and (3) concomitant CAD and/or CVD. RESULTS: RF control was less frequent in patients with PAD (n=8322), compared with those with CAD or CVD (but no PAD, n=47492) [blood pressure; glycemia; total cholesterol; smoking cessation (each P<0.001)]. Factors independently associated with optimal RF control in patients with PAD were male gender (OR=1.9); residence in North America (OR=3.5), Japan (OR=2.5) or Latin America (OR=1.5); previous coronary revascularization (OR=1.3); and statin use (OR=1.4); whereas prior leg amputation was a negative predictor (OR=0.7) (P<0.001). Optimal RF control was associated with fewer 1-year CV ischemic symptoms or events. CONCLUSIONS: Patients with PAD do not achieve RF control as frequently as individuals with CAD or CVD. Improved RF control is associated with a positive impact on 1-year CV event rates.
Authors:
Patrice P Cacoub; Maria Teresa B Abola; Iris Baumgartner; Deepak L Bhatt; Mark A Creager; Chiau-Suong Liau; Shinya Goto; Joachim Röther; P Gabriel Steg; Alan T Hirsch;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2008-10-31
Journal Detail:
Title:  Atherosclerosis     Volume:  204     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  e86-92     Citation Subset:  IM    
Affiliation:
Pierre and Marie Curie University-Paris 6, and AP HP, Hospital La Pitié-Salpêtrière, Paris, France. patrice.cacoub@psl.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Atherosclerosis / complications,  therapy*
Cardiovascular Diseases / etiology,  prevention & control*
Cerebrovascular Disorders / complications,  therapy
Coronary Artery Disease / complications,  therapy
Female
Humans
Male
Middle Aged
Odds Ratio
Peripheral Vascular Diseases / complications,  therapy*
Proportional Hazards Models
Prospective Studies
Registries
Risk Assessment
Risk Factors
Thrombosis / complications,  therapy*
Time Factors
Investigator
Investigator/Affiliation:
Mark Alberts / ; Deepak L Bhatt / ; Ralph D'Agostino / ; Kim Eagle / ; Shinya Goto / ; Alan T Hirsch / ; Chiau-Suong Liau / ; Jean-Louis Mas / ; E Magnus Ohman / ; Joachim Röther / ; Sidney C Smith / ; P Gabriel Steg / ; Peter W F Wilson / ; Christopher Reid / ; Franz Aichner / ; Thomas Wascher / ; Patrice Laloux / ; Julia Djorgova / ; Eric A Cohen / ; Ramon Corbalan / ; L V Chuanzhen / ; Ilkka Tierala / ; Jean-Louis Mas / ; Patrice Cacoub / ; Gilles Montalescot / ; Klaus Parhofer / ; Uwe Zeymer / ; Joachim Röther / ; Moses Elisaf / ; Romulo Lopez / ; Juliana Chan / ; György Pfliegler / ; Bambang Sutrisna / ; Avi Porath / ; Yasuo Ikeda / ; Ismail Khalil / ; Ruta Babarskiene / ; Robaayah Zambahari / ; Efrain Gaxiola / ; Don Poldermans / ; Maria Teresa B Abola / ; Victor Gil / ; Constantin Popa / ; Yuri Belenkov / ; Elizaveta Panchenko / ; Hassan Chamsi-Pasha / ; Yeo Tiong Cheng / ; Oh Dong-Joo / ; Carmen Suarez / ; Iris Baumgartner / ; Chiau-Suong Liau / ; Piyamitr Sritara / ; Wael Al Mahmeed / ; Jonathan Morrell / ; Vira Tseluyko / ; Mark Alberts / ; Robert M Califf / ; Christopher P Cannon / ; Kim Eagle / ; Alan T Hirsch /

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