| Cardiovascular responses to phenylephrine and sodium nitroprusside during acute coronary occlusion in dogs. | |
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MedLine Citation:
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PMID: 7883288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of administration of pressor agent phenylephrine (PE) and depressor agent, sodium nitroprusside (SNP) (10-40 micrograms/kg) on arterial blood pressure (ABP) and heart rate (HR) were investigated during acute occlusion of left anterior descending coronary artery (LAD) in anaesthetized, artificially ventilated dogs with and without the influence of selective blockade of autonomic nervous system (ANS). ABP response to PE was significantly (P < 0.05) attenuated following 4 hrs of LAD occlusion in all the four groups of animals. SNP response at higher dose (40 micrograms/kg) was also significantly (P < 0.05) attenuated 4 hrs after LAD occlusion in ANS intact, beta-blocked and atropinized groups. The bradycardia response to PE after LAD occlusion was abolished in vagotomized group while in the other three groups, it was significantly attenuated following 4 hrs of LAD occlusion. The tachycardia response to SNP was significantly (P < 0.05) attenuated 4 hrs after LAD occlusion in ANS intact and atropinized animals. The response was abolished in beta-blocked animals and no significant change occurred (P > 0.05) in vagotomized group. This study suggests that the cardiovascular reflex effects of PE and SNP are significantly attenuated following acute LAD occlusion. Blocking any of the components of ANS changed this responsiveness. |
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Authors:
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M E Hussain; M Fahim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of physiology and pharmacology Volume: 38 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-04-12 Completed Date: 1995-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: INDIA |
Other Details:
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Languages: eng Pagination: 252-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Animals Blood Pressure / drug effects Coronary Circulation / drug effects* Coronary Disease / drug therapy* Disease Models, Animal Dogs Dose-Response Relationship, Drug Female Heart Rate / drug effects Male Nitroprusside / pharmacology* Phenylephrine / pharmacology* Vagotomy |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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