Document Detail


Cardiovascular responses to parathyroid hormone.
MedLine Citation:
PMID:  4025539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthetic amino terminal fragment of parathyroid hormone, PTH-(1-34), is a potent coronary artery vasodilator in the dog. In the present study, using instrumented open-chest dogs, we have performed the initial characterization of this effect and showed other dose-related cardiovascular effects of the hormone. A near-maximal flow response was obtained after intracoronary injection of 0.024 nmol X kg-1 PTH-(1-34) with minor, if any, concomitant changes in mean blood pressure, contractile force, or heart rate. At higher doses, mean blood pressure decreased while contractile force and heart rate increased in dose-dependent fashion. Infusion of PTH-(1-34) for 20 min showed that the vasodilatory effect could be sustained without a concomitant decrease in mean arterial pressure. Pharmacological characterization showed for the first time that the coronary response to PTH-(1-34) was unaltered in the presence of beta- or alpha-adrenergic, muscarinic, or histaminergic blockades. We conclude that PTH-(1-34), an endogenous circulating calcemic peptide, produces a large increase in coronary blood flow at doses sufficiently low to preclude complicating effects on blood pressure, contractile force, and heart rate. Furthermore, the results suggest that the vasodilatory effects may be specific.
Authors:
M F Crass; P L Moore; M L Strickland; P K Pang; M S Citak
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  249     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-11     Completed Date:  1985-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E187-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Blood Pressure / drug effects
Cimetidine / pharmacology
Coronary Circulation / drug effects
Coronary Vessels
Dogs
Heart Rate / drug effects
Hemodynamics / drug effects*
Infusions, Intra-Arterial
Injections, Intra-Arterial
Myocardial Contraction / drug effects
Parathyroid Hormone / pharmacology*
Peptide Fragments / pharmacology*
Phentolamine / pharmacology
Promethazine / pharmacology
Propranolol / pharmacology
Teriparatide
Grant Support
ID/Acronym/Agency:
HL-07474/HL/NHLBI NIH HHS; HL-29108/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 0/Peptide Fragments; 50-60-2/Phentolamine; 51-55-8/Atropine; 51481-61-9/Cimetidine; 52232-67-4/Teriparatide; 525-66-6/Propranolol; 60-87-7/Promethazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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