Document Detail

Cardiovascular responses to a newly developed cardiotonic agent, ZSY-39 [4-methyl-5-(4-pyridinyl)-thiazole-2-carboxyamide] in dog cross-circulated atrial and ventricular preparations.
MedLine Citation:
PMID:  3599412     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of ZSY-39 [4-methyl-5-(4-pyridinyl)-thiazole-2-carboxyamide] were investigated in isolated and blood-perfused atrial and ventricular muscles perfused with donor's arterial blood. When ZSY-39 was given i.v. to the intact donor dog, hypotension with a slight tachycardia was induced at a dose range of 30-1,000 micrograms/kg. At the same time, slight positive chronotropic and inotropic responses appeared in isolated, perfused atria at i.v. doses of 300 and 1,000 micrograms/kg ZSY-39, indicating a relatively dominant inotropic action. Direct injection of ZSY-39 into the cannulated sinus node artery of the isolated atrium produced positive chronotropic and inotropic responses in a dose-related manner (1 to 300 micrograms). ZSY-39 also induced a dose-dependent increase in developed tension in the isolated ventricle. The positive chronotropic and inotropic effects of ZSY-39 were not modified by an adequate dose of propranolol which completely blocked norepinephrine-induced positive chronotropic and inotropic responses. From these results, it is concluded that ZSY-39 has mild cardiotonic properties, showing relatively selective positive inotropic activity.
S Chiba; Y Furukawa; K Saegusa; Y Ogiwara; M Takeda
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  28     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-08-14     Completed Date:  1987-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  253-60     Citation Subset:  IM    
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MeSH Terms
Cardiotonic Agents / pharmacology*
Cross Circulation*
Dose-Response Relationship, Drug
Heart / drug effects*
Heart Conduction System / drug effects
Heart Rate / drug effects
Hypotension / chemically induced
Myocardial Contraction / drug effects
Phosphodiesterase Inhibitors / pharmacology*
Pyridines / pharmacology*
Thiazoles / pharmacology*
Reg. No./Substance:
0/Cardiotonic Agents; 0/Phosphodiesterase Inhibitors; 0/Pyridines; 0/Thiazoles; 106853-15-0/4-methyl-5-(4-pyridinyl)thiazole-2-carboxamide

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