| Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus. | |
| | |
MedLine Citation:
|
PMID: 19766978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The objective was to characterize the effect of glucocorticoid treatment on fetal organ blood flow and regional cerebral blood flow in normally grown fetuses and fetuses with intrauterine fetal growth restriction (IUGR). STUDY DESIGN: Studies were undertaken in both control and IUGR fetal sheep; growth restriction was induced by ligation of 1 umbilical artery. Fetuses received colored microspheres for organ blood flow calculations before and after 2 maternal betamethasone injections (BM1 and BM2). RESULTS: Following BM1, cardiac output was significantly decreased in the control fetuses and blood flow to the heart and placenta was unchanged, whereas total cerebral blood flow was significantly decreased (P<.001), consistent with cerebral vasoconstriction. In the fetuses with IUGR, the cardiac output was significantly increased at +33 hours relative to BM1, and blood flow was increased in all organs; notably, there was a 2-fold increase in cerebral blood flow (P=.03). CONCLUSION: The cardiovascular response of the fetus with IUGR to glucocorticoids is profoundly different from the control fetuses, which may induce both short- and long-term injury. |
| | |
Authors:
|
Suzanne L Miller; Veena G Supramaniam; Graham Jenkin; David W Walker; Euan M Wallace |
Related Documents
:
|
1683418 - Ultrasonographic velocimetry of the fetal ductus venosus. 12635738 - Nucleated red blood cell counts in growth-restricted neonates with absent or reversed-e... 2002978 - Association of umbilical venous with inferior vena cava blood flow velocities. 3323458 - Color flow mapping in obstetrics. 16874558 - Oxygen mass transport in a compliant carotid bifurcation model. 12234948 - High doses of vitamin c reverse escherichia coli endotoxin-induced hyporeactivity to ac... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-20 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 201 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-07 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 613.e1-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Monash Institute of Medical Research, Monash University, Clayton, VIC, Australia. suzie.miller@med.monash.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Betamethasone / pharmacology*, therapeutic use Cardiovascular System / drug effects* Cerebrovascular Circulation Coronary Circulation Female Fetal Growth Retardation / drug therapy* Fetus Glucocorticoids / pharmacology*, therapeutic use Placenta / blood supply Pregnancy Sheep |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids; 378-44-9/Betamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Osteopathic manipulative treatment of back pain and related symptoms during pregnancy: a randomized ...
Next Document: Maternal activity restriction and the prevention of preterm birth.