Document Detail


Cardiovascular responses to cold exposure.
MedLine Citation:
PMID:  20036896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of hypertension is increased in winter and in cold regions of the world. Cold temperatures make hypertension worse and trigger cardiovascular complications (stroke, myocardial infarction, heart failure, etc.). Chronic or intermittent exposure to cold causes hypertension and cardiac hypertrophy in animals. The purpose of this review is to provide the recent advances in the mechanistic investigation of cold-induced hypertension (CIH). Cold temperatures increase the activities of the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS). The SNS initiates CIH via the RAS. Cold exposure suppresses the expression of eNOS and formation of NO, increases the production of endothelin-1 (ET-1), up-regulates ETA receptors, but down-regulates ETB receptors. The roles of these factors and their relations in CIH will be reviewed.
Authors:
Zhongjie Sun
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  2     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-07-01     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-503     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cold Temperature*
Endothelin-1 / metabolism
Gene Expression Regulation / physiology*
Humans
Hypertension / etiology*
Nitric Oxide / biosynthesis
Nitric Oxide Synthase Type III / metabolism
Receptors, Endothelin / metabolism
Renin-Angiotensin System / physiology*
Sympathetic Nervous System / physiopathology*
Grant Support
ID/Acronym/Agency:
R01 HL-077490/HL/NHLBI NIH HHS; R01 HL077490/HL/NHLBI NIH HHS; R01 HL077490-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endothelin-1; 0/Receptors, Endothelin; 31C4KY9ESH/Nitric Oxide; EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type III
Comments/Corrections

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