| Cardiovascular responses to cold exposure. | |
| | |
MedLine Citation:
|
PMID: 20036896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The prevalence of hypertension is increased in winter and in cold regions of the world. Cold temperatures make hypertension worse and trigger cardiovascular complications (stroke, myocardial infarction, heart failure, etc.). Chronic or intermittent exposure to cold causes hypertension and cardiac hypertrophy in animals. The purpose of this review is to provide the recent advances in the mechanistic investigation of cold-induced hypertension (CIH). Cold temperatures increase the activities of the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS). The SNS initiates CIH via the RAS. Cold exposure suppresses the expression of eNOS and formation of NO, increases the production of endothelin-1 (ET-1), up-regulates ETA receptors, but down-regulates ETB receptors. The roles of these factors and their relations in CIH will be reviewed. |
| | |
Authors:
|
Zhongjie Sun |
Related Documents
:
|
1208596 - The relationship between sodium excretion and renin secretion by the perfused kidney. 7033506 - Renin-dependence of drinking induced by partial aortic obstruction in the dog. 6368236 - Renal tuberculosis and hypertension: value of the renal vein renin ratio. 18062896 - Intracardiac and intrarenal renin-angiotensin systems: mechanisms of cardiovascular and... 6855636 - Dog lymph flow in increased capillary permeability states. 16399046 - High-frequency jet ventilation: utility in posterior left atrial catheter ablation. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience (Elite edition) Volume: 2 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2010 |
Date Detail:
|
Created Date: 2009-12-28 Completed Date: 2010-07-01 Revised Date: 2011-07-18 |
Medline Journal Info:
|
Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
|
Languages: eng Pagination: 495-503 Citation Subset: IM |
Affiliation:
|
Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cold Temperature* Endothelin-1 / metabolism Gene Expression Regulation / physiology* Humans Hypertension / etiology* Nitric Oxide / biosynthesis Nitric Oxide Synthase Type III / metabolism Receptors, Endothelin / metabolism Renin-Angiotensin System / physiology* Sympathetic Nervous System / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL-077490/HL/NHLBI NIH HHS; R01 HL077490-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Endothelin-1; 0/Receptors, Endothelin; 10102-43-9/Nitric Oxide; EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical biomarkers in esophageal adenocarcinoma.
Next Document: Clinical biomarkers in sepsis.