Document Detail

Cardiovascular responses to avoidance conditioning in the dog: effects of alpha adrenergic blockade.
MedLine Citation:
PMID:  934718     Owner:  NLM     Status:  MEDLINE    
Laboratory dogs were trained to press a response panel to postpone shocks during daily one-hour avoidance conditioning periods. Each dog was also confined in the experimental environment for 5 hours prior to the avoidance periods. Blood pressure and heart rate were monitored continuously during these experiments from chronically indwelling arterial catheters. Extended training resulted in the emergence of a cardiovascular response pattern during the pre-avoidance interval characterized by gradual increases in blood pressure together with decreases in heart rate. Elevations in both blood pressure and heart rate were sustained during the avoidance periods. During sessions in which alpha adrenergic activity was suppressed by phenoxybenzamine, absolute levels of blood pressure were found to be lower than during control (non-drug) sessions, but a progressive rise in blood pressure continued to be observed during pre-avoidance. These results suggest that sustained cardiovascular responses during avoidance periods are associated with activation of the sympathetic nervous system, but that the gradual rise in blood pressure during pre-avoidance is due to other factors.
D E Anderson; J E Yingling; J V Brady
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pavlovian journal of biological science     Volume:  11     ISSN:  0093-2213     ISO Abbreviation:  Pavlov J Biol Sci     Publication Date:    1976 Jul-Sep
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414243     Medline TA:  Pavlov J Biol Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  150-61     Citation Subset:  IM    
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MeSH Terms
Avoidance Learning / drug effects,  physiology*
Blood Pressure* / drug effects
Conditioning, Operant / drug effects,  physiology*
Heart Rate* / drug effects
Phenoxybenzamine / pharmacology*
Sympathetic Nervous System / physiology
Reg. No./Substance:

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