Document Detail


Cardiovascular responses produced by the injection of dopamine into the cerebral ventricles of the unanaesthetized dog.
MedLine Citation:
PMID:  465876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 The injection of dopamine (100 to 500 microgram) into the cerebral ventricles (i.c.v.) of 10 unanaesthetized dogs produced a dose-dependent increase in arterial blood pressure and heart rate. The dogs licked, swallowed, sometimes vomited and became sedated. 2 Autonomic ganglion blockade with hexamethonium (10 mg/kg i.v.) abolished cardiovascular responses to i.c.v. dopamine, indicating that dopamine was exerting its effect within the central nervous system. 3 The dopamine receptor antagonists, haloperidol (500 microgram), chlorpromazine (200 micrograms) and ergometrine (500 micrograms), each given i.c.v., sugsequently abolished the cardiovascular responses to dopamine. 4 Pretreatment with either the beta-adrenoceptor antagonist, propranolol (600 microgram) or the alpha-adrenoceptor antagonist, phentolamine (1 mg) given i.c.v. had no significant effect on the response to dopamine. 5 It is suggested that dopamine injected into the cerebral ventricles of the unanesthetized dog causes hypertension and tachycardia by activating central dopamine receptors.
Authors:
W J Lang; O L Woodman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  66     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Cerebral Ventricles / drug effects,  physiology*
Chlorpromazine / pharmacology
Dogs
Dopamine / administration & dosage,  pharmacology*
Ergonovine / pharmacology
Female
Haloperidol / pharmacology
Heart Rate / drug effects*
Hexamethonium Compounds / pharmacology
Injections, Intraventricular
Male
Phentolamine / pharmacology
Propranolol / pharmacology
Chemical
Reg. No./Substance:
0/Hexamethonium Compounds; 50-53-3/Chlorpromazine; 50-60-2/Phentolamine; 52-86-8/Haloperidol; 525-66-6/Propranolol; 60-79-7/Ergonovine
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