| Cardiovascular responses produced by the injection of dopamine into the cerebral ventricles of the unanaesthetized dog. | |
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MedLine Citation:
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PMID: 465876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 The injection of dopamine (100 to 500 microgram) into the cerebral ventricles (i.c.v.) of 10 unanaesthetized dogs produced a dose-dependent increase in arterial blood pressure and heart rate. The dogs licked, swallowed, sometimes vomited and became sedated. 2 Autonomic ganglion blockade with hexamethonium (10 mg/kg i.v.) abolished cardiovascular responses to i.c.v. dopamine, indicating that dopamine was exerting its effect within the central nervous system. 3 The dopamine receptor antagonists, haloperidol (500 microgram), chlorpromazine (200 micrograms) and ergometrine (500 micrograms), each given i.c.v., sugsequently abolished the cardiovascular responses to dopamine. 4 Pretreatment with either the beta-adrenoceptor antagonist, propranolol (600 microgram) or the alpha-adrenoceptor antagonist, phentolamine (1 mg) given i.c.v. had no significant effect on the response to dopamine. 5 It is suggested that dopamine injected into the cerebral ventricles of the unanesthetized dog causes hypertension and tachycardia by activating central dopamine receptors. |
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Authors:
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W J Lang; O L Woodman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 66 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1979 Jun |
Date Detail:
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Created Date: 1979-10-26 Completed Date: 1979-10-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 235-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Cerebral Ventricles / drug effects, physiology* Chlorpromazine / pharmacology Dogs Dopamine / administration & dosage, pharmacology* Ergonovine / pharmacology Female Haloperidol / pharmacology Heart Rate / drug effects* Hexamethonium Compounds / pharmacology Injections, Intraventricular Male Phentolamine / pharmacology Propranolol / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 50-53-3/Chlorpromazine; 50-60-2/Phentolamine; 52-86-8/Haloperidol; 525-66-6/Propranolol; 60-79-7/Ergonovine |
| Comments/Corrections | |
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