Document Detail


Cardiovascular responses in hypertensive outpatients starting oral propranolol, determined from the brachial pulse upstroke.
MedLine Citation:
PMID:  7439235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Simultaneous measurement of brachial artery pressures, systolic time intervals, initial pulse upstroke gradient and pulse rate was made in 7 adult hypertensive outpatients during rest supine and during bicycle ergometry at 2 different work rates. Measurements were repeated after 1, 6 and 13 wk on oral propranolol 80 mg thrice daily. Rise of pulse upstroke period (reversed after 1 wk) and of inflection time--analogous with preejection period--and fall of inflection, or diastolic, pressure (most marked at 1 wk) can be explained by early reduction of myocardial contractility and pulse rate. The fall of upstroke period, of peak, or systolic, pressure and of pulse rate (more marked after 1 wk) is related to a later 'adaptive' decrease in peripheral resistance. Much useful information can be obtained by such simple examination of the characteristics of the pulse wave in the brachial artery without complex, albeit noninvasive, cardiac investigations.
Authors:
R Carlisle; A Porter; E B Raftery; I D Hill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardiology     Volume:  12     ISSN:  0301-4711     ISO Abbreviation:  Eur J Cardiol     Publication Date:  1980  
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404054     Medline TA:  Eur J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Blood Pressure / drug effects
Female
Hemodynamics / drug effects
Humans
Hypertension / drug therapy*
Male
Middle Aged
Myocardial Contraction / drug effects
Physical Exertion
Propranolol / pharmacology,  therapeutic use*
Pulse / drug effects*
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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