Document Detail

Cardiovascular responses evoked by leptin acting on neurons in the ventromedial and dorsomedial hypothalamus.
MedLine Citation:
PMID:  12939234     Owner:  NLM     Status:  MEDLINE    
Leptin, a circulating hormone produced by adipose tissue, is believed to act on the hypothalamus to increase sympathetic vasomotor activity, in addition to its well-known effects on appetite and energy expenditure. In this study, we determined the cardiovascular effects of direct application of leptin to specific cell groups within the hypothalamus that are known to be activated by circulating leptin. In rats anesthetized with urethane, microinjections of leptin (16 ng in 20 nL solution) were made into the ventromedial hypothalamic nucleus, dorsomedial hypothalamic nucleus, and paraventricular nucleus. Compared with vehicle solution, microinjections of leptin into the ventromedial hypothalamic nucleus evoked significant increases in arterial pressure and renal sympathetic nerve activity, but not heart rate. In contrast, microinjections of leptin into the dorsomedial hypothalamic nucleus evoked significant increases in arterial pressure and heart rate but not renal sympathetic nerve activity, whereas microinjections of leptin into the paraventricular nucleus had no significant effect on any of the measured cardiovascular variables. These results indicate that the ventromedial and dorsomedial hypothalamic regions might be important sites at which leptin activation leads to increases in sympathetic vasomotor activity and heart rate, as occurs in obesity-related hypertension.
Ainsley J Marsh; Marco A P Fontes; Suzanne Killinger; Dorota B Pawlak; Jaimie W Polson; Roger A L Dampney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-08-25
Journal Detail:
Title:  Hypertension     Volume:  42     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-03     Completed Date:  2003-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-93     Citation Subset:  IM    
Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW, Australia.
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MeSH Terms
Blood Pressure / drug effects
Dorsomedial Hypothalamic Nucleus / cytology,  drug effects,  physiology*
Heart Rate / drug effects
Kidney / innervation
Leptin / administration & dosage,  pharmacology*
Neurons / drug effects,  physiology
Rats, Sprague-Dawley
Sympathetic Nervous System / drug effects,  physiology
Ventromedial Hypothalamic Nucleus / cytology,  drug effects,  physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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