Document Detail

Cardiovascular responses elicited during binge administration of cocaine.
MedLine Citation:
PMID:  14568316     Owner:  NLM     Status:  MEDLINE    
Cocaine use is often characterized by a repeated pattern of frequent administrations (binge) followed by periods of abstinence. The repeated binge administration of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) alters cardiovascular function and the arterial pressure and heart rate responses elicited by these drugs. Whether repeated binges of cocaine similarly affect cardiovascular function and cardiovascular responsiveness is unknown. Radiotelemetry was used to record the cardiovascular responses elicited during three successive cocaine binges (5 mg/kg, t.i.d., for 4 days) in conscious, unrestrained rats. Each binge was separated by a 10-day cocaine-free period. The effects of cocaine administration on vascular reactivity and vasovagal, Bezold-Jarisch reflex function were also evaluated. The intravenous administration of cocaine increased both mean arterial pressure (MAP) and heart rate. The arterial pressure and heart rate responses elicited by cocaine, both within and between the binges, were remarkably similar. The arterial pressure and heart rate responses elicited by the intravenous administration of sodium nitroprusside, acetylcholine and phenylephrine before each binge and 10 days after the last binge were not altered after the binge administration of cocaine. Likewise, Bezold-Jarisch reflex function elicited by intravenous serotonin was unchanged after the binge administration of cocaine. These results indicate that the administration of cocaine using this repeated binge model does not alter the arterial pressure and heart rate responses elicited by the drug, nor does it alter the cardiovascular responses elicited by a variety of vasoactive substances.
Alissa R Hicks; Brian A Ogden; Kurt J Varner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  80     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-21     Completed Date:  2003-12-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  IM    
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA.
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MeSH Terms
Acetylcholine / pharmacology
Blood Pressure / drug effects*
Cardiovascular System / drug effects*
Cocaine / pharmacology*
Cocaine-Related Disorders / physiopathology*
Disease Models, Animal
Drug Interactions
Heart Rate / drug effects*
Nitroprusside / pharmacology
Rats, Sprague-Dawley
Serotonin / pharmacology
Vasodilator Agents / pharmacology
Grant Support
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 50-36-2/Cocaine; 50-67-9/Serotonin; 51-84-3/Acetylcholine

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