Document Detail

Cardiovascular responses, arterial oxygen saturation and plasma catecholamine concentration during upper gastrointestinal endoscopy using conscious sedation with midazolam or propofol.
MedLine Citation:
PMID:  9785067     Owner:  NLM     Status:  MEDLINE    
Hypoventilation as a consequence of deep intravenous sedation is the most frequently reported cause of cardiac arrest during upper gastrointestinal endoscopy (UGIE). Haemodynamic stress can contribute to myocardial ischaemia; therefore, this study was designed to observe prospectively the cardiorespiratory changes during UGIE using either midazolam or propofol for conscious sedation. Thirty-four patients, aged 50 years and older, ASA physical status I-III, scheduled for elective UGIE with sedation, were studied. Oxygen saturation, heart rate, non-invasive blood pressure and Holter ECG were recorded continuously starting 15 min before sedation until 15 min after the endoscopy. In addition, plasma catecholamine concentrations were determined. The results of this study are consistent with previous reports that cardiopulmonary events may occur during endoscopy, with or without sedation. Both midazolam and propofol sedation may provide some protection against haemodynamic stress in response to insertion and manipulation of the endoscope, but sedation can also contribute to the occurrence of hypoxaemia.
V L Oei-Lim; C J Kalkman; J F Bartelsman; J C Res; H B van Wezel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  15     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-17     Completed Date:  1998-12-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  535-43     Citation Subset:  IM    
Department of Anaesthesia, Academic Medical Centre, University of Amsterdam, The Netherlands.
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MeSH Terms
Anoxia / etiology
Blood Pressure / drug effects
Conscious Sedation*
Electrocardiography, Ambulatory / drug effects
Endoscopy, Gastrointestinal*
Epinephrine / blood*
Heart / drug effects*
Heart Rate / drug effects
Hypnotics and Sedatives / administration & dosage*
Lung / drug effects
Midazolam / administration & dosage*
Middle Aged
Norepinephrine / blood*
Oxygen / blood*
Propofol / administration & dosage*
Prospective Studies
Stress, Physiological / prevention & control
Reg. No./Substance:
0/Hypnotics and Sedatives; 2078-54-8/Propofol; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 59467-70-8/Midazolam; 7782-44-7/Oxygen

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