Document Detail

Cardiovascular response to renin substrate microinjection into the central nucleus of the amygdala of rats.
MedLine Citation:
PMID:  17426597     Owner:  NLM     Status:  MEDLINE    
Central nucleus of the amygdala is involved in cardiovascular regulation. Although most components of the renin-angiotensin system have been found to be distributed in amygdala, renin expression in brain has remained controversial. This work was undertaken to elucidate the extent of renin presence in this nucleus. A cannula was implanted bilaterally into the central nucleus of the amygdala. Mean arterial pressure and heart rate were directly measured via indwelling femoral artery cannula post bilateral intra central nucleus of the amygdala microinjection of renin substrate. Renin substrate microinjection dose-dependently increased mean arterial pressure and heart rate, whereas captopril, saralasin and losartan pretreatment inhibited these effects. The results suggest the presence of local renin or similar proteases in this nucleus.
Behnam Heshmatian; Mohsen Parviz; Sayed Morteza Karimian; Mansoor Keshavarz; Hamid Sohanaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  18     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  675-8     Citation Subset:  IM    
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran.
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MeSH Terms
Amygdala / drug effects,  metabolism*
Angiotensinogen / administration & dosage*,  metabolism
Blood Pressure / drug effects
Cardiovascular System / drug effects*,  metabolism
Dose-Response Relationship, Drug
Heart Rate / drug effects
Injections, Intraventricular
Rats, Sprague-Dawley
Renin / metabolism
Serine Proteinase Inhibitors / administration & dosage*,  metabolism
Reg. No./Substance:
0/Serine Proteinase Inhibitors; 11002-13-4/Angiotensinogen; EC

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