| Cardiovascular response to renin substrate microinjection into the central nucleus of the amygdala of rats. | |
| | |
MedLine Citation:
|
PMID: 17426597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Central nucleus of the amygdala is involved in cardiovascular regulation. Although most components of the renin-angiotensin system have been found to be distributed in amygdala, renin expression in brain has remained controversial. This work was undertaken to elucidate the extent of renin presence in this nucleus. A cannula was implanted bilaterally into the central nucleus of the amygdala. Mean arterial pressure and heart rate were directly measured via indwelling femoral artery cannula post bilateral intra central nucleus of the amygdala microinjection of renin substrate. Renin substrate microinjection dose-dependently increased mean arterial pressure and heart rate, whereas captopril, saralasin and losartan pretreatment inhibited these effects. The results suggest the presence of local renin or similar proteases in this nucleus. |
| | |
Authors:
|
Behnam Heshmatian; Mohsen Parviz; Sayed Morteza Karimian; Mansoor Keshavarz; Hamid Sohanaki |
Related Documents
:
|
1071607 - Determination of renin-dependency and sodium-dependency in the three renin sub-groups o... 15372097 - Prostanoids and blood pressure: which way is up? 3128117 - Effect of vasopressin blockade on blood pressure during water deprivation in intact and... 637637 - The multiple factors affecting plasma renin activity in essential hypertension. 22379217 - Actions to control high blood pressure among hypertensive adults in texas counties alon... 3353587 - Effect of the larynx on ventilation and respiratory pattern in anesthetized rabbits. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroreport Volume: 18 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2007 May |
Date Detail:
|
Created Date: 2007-04-11 Completed Date: 2007-06-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
|
Languages: eng Pagination: 675-8 Citation Subset: IM |
Affiliation:
|
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amygdala
/
drug effects,
metabolism* Angiotensinogen / administration & dosage*, metabolism Animals Blood Pressure / drug effects Cardiovascular System / drug effects*, metabolism Dose-Response Relationship, Drug Heart Rate / drug effects Injections, Intraventricular Male Microinjections Rats Rats, Sprague-Dawley Renin / metabolism Serine Proteinase Inhibitors / administration & dosage*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Serine Proteinase Inhibitors; 11002-13-4/Angiotensinogen; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve.
Next Document: Water avoidance stress activates colonic myenteric neurons in female rats.