Document Detail

Cardiovascular response to physical exercise in adult patients after atrial correction for transposition of the great arteries assessed with magnetic resonance imaging.
MedLine Citation:
PMID:  15145879     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess with magnetic resonance imaging (MRI) cardiovascular function in response to exercise in patients after atrial correction of transposition of the great arteries (TGA).
METHODS: Cardiac function at rest and during submaximal exercise was assessed with MRI in 27 patients with TGA (mean (SD) age 26 (5) years) late (23 (2) years) after atrial correction and in 14 control participants (25 (5) years old).
RESULTS: At rest, only right ventricular ejection fraction was significantly lower in patients than in controls (56 (7)% v 65 (7)%, p < 0.05). In response to exercise, increases in right ventricular end diastolic (155 (55) ml to 163 (57) ml, p < 0.05) and right ventricular end systolic volumes (70 (34) ml to 75 (36) ml, p < 0.05) were observed in patients. Furthermore, right and left ventricular stroke volumes and ejection fraction did not increase significantly in patients. Changes in right ventricular ejection fraction with exercise correlated with diminished exercise capacity (r = 0.43, p < 0.05).
CONCLUSIONS: In patients with atrially corrected TGA, MRI showed an abnormal response to exercise of both systemic right and left ventricles. Exercise MRI provides a tool for close monitoring of cardiovascular function in these patients, who are at risk for late death.
A A W Roest; H J Lamb; E E van der Wall; H W Vliegen; J G van den Aardweg; P Kunz; A de Roos; W A Helbing
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  90     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-17     Completed Date:  2004-06-15     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  678-84     Citation Subset:  AIM; IM    
Department of Paediatric Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.
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MeSH Terms
Blood Pressure / physiology
Exercise / physiology*
Exercise Test
Heart Atria / surgery
Heart Rate / physiology
Magnetic Resonance Angiography / methods*
Oxygen Consumption / physiology
Transposition of Great Vessels / physiopathology*,  surgery
Ventricular Function / physiology*
Ventricular Function, Left / physiology
Ventricular Function, Right / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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