Document Detail

Cardiovascular response to epinephrine-containing local anesthesia in patients with cardiovascular disease.
MedLine Citation:
PMID:  11740477     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of the present study was to examine the safety of epinephrine-containing local anesthesia for use on patients with cardiovascular disease. STUDY DESIGN: Twenty-seven patients with cardiovascular disease were studied. The cardiac functional capacity of 9 patients was New York Heart Association class I; 11, class II; and 7, class III. Hemodynamic responses to intraoral injection of 1.8 mL of 2% lidocaine with 1:80,000 epinephrine were measured with impedance cardiography. RESULTS: Systolic blood pressure and heart rate increased by 4.1% and 5.1%, respectively, immediately after the lidocaine-epinephrine injection. Consequently, rate pressure product increased by 10.0%. Cardiac index increased by 14.2%, and total peripheral resistance decreased by approximately 10%. No patient complained of cardiac symptoms. There were no significant differences in hemodynamic responses related to the extent of the cardiac functional capacity. CONCLUSION: We concluded that lidocaine-epinephrine was safe and had few, if any, hemodynamic consequences in patients with cardiovascular disease.
H Niwa; M Sugimura; Y Satoh; A Tanimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  92     ISSN:  1079-2104     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-03-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  610-6     Citation Subset:  D; IM    
Department of Dental Anesthesiology, Osaka University, Suita, Japan.
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MeSH Terms
Anesthesia, Dental*
Anesthesia, Local*
Anesthetics, Local / administration & dosage
Blood Pressure / drug effects
Cardiac Output / drug effects
Cardiovascular Diseases / physiopathology*
Dental Care for Chronically Ill*
Epinephrine / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Lidocaine / administration & dosage
Middle Aged
Stroke Volume / drug effects
Vascular Resistance / drug effects
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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