Document Detail

Cardiovascular response to dynamic treadmill exercise in patients with essential hypertension before and after therapy with atenolol or captopril.
MedLine Citation:
PMID:  2084084     Owner:  NLM     Status:  MEDLINE    
Thirty eight patients with essential hypertension and 20 healthy volunteers were subjected to treadmill exercise test. The hypertensives were then controlled with atenolol or captopril by randomly forming two groups of 19 patients each, and treadmill evaluation was repeated. The resting rate-pressure product (RPP) and myocardial oxygen consumption (MVO2), as well as peak RPP and MVO2 and recovery time, were increased and exercise duration decreased significantly in uncontrolled hypertensives (p less than 0.001). Control of hypertension resulted in significant improvement of exercise performance in both the groups. Atenolol, when compared to captopril, resulted in better exercise conditioning with considerable lowering of resting and peak RPP and MVO2 (p less than 0.001), though the difference in exercise duration, maximum work load and recovery time were not significant (p greater than 0.05). Thus, where myocardial oxygen consumption is an important consideration while treating hypertension, atenolol offers a better choice.
P K Shah; M Lakhotia; M Chittora; S Mehta; S Mehta; R Vyas; M Parihar
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  38     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-05-14     Completed Date:  1991-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  781-4     Citation Subset:  IM    
Department of Internal Medicine, Dr SN Medical College Hospital, Jodhpur.
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MeSH Terms
Atenolol / therapeutic use*
Blood Pressure / drug effects
Body Weight
Captopril / therapeutic use*
Exercise Test*
Hemodynamics / drug effects*,  physiology
Hypertension / drug therapy*,  physiopathology
Middle Aged
Reference Values
Reg. No./Substance:
29122-68-7/Atenolol; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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