Document Detail

Cardiovascular response to acute hypoxia in double-muscled calves.
MedLine Citation:
PMID:  1620964     Owner:  NLM     Status:  MEDLINE    
Hypoxic-induced pulmonary hypertension is known to be intensive in the bovine species and sometimes leads to pathological cardiac repercussions. On the other hand, doubled-muscled cattle are predisposed to develop hypoxaemia during exercise and with respiratory diseases. Therefore the purpose of this study was to investigate the cardiovascular response to acute hypoxia in double-muscled calves compared with calves of standard conformation. Pulmonary arterial pressure, electrocardiogram and blood temperature were simultaneously recorded, arterial blood was sampled for blood gas analysis and cardiac output was determined in six Friesian calves and six double-muscled calves of the Belgian White and Blue breed(BWB) when breathing air (fractional inspiratory oxygen concentration [FIO2]: 21 per cent) and when breathing a hypoxic gas mixture (FIO2: 10 per cent). All the absolute values of the measured parameters were significantly (P less than or equal to 0.001) different between the two breeds, except heart rate and arterial blood gas values. The pattern of hypoxic-induced decrease in arterial PO2 was similar in the two breeds of calves, suggesting that the pulmonary exchange capacities during hypoxia are no less efficient in double-muscled calves than in calves of standard conformation. Similarly, the percentage of variation of the mean pulmonary arterial pressure from its normoxic to its hypoxic value was the same in the two breeds of calves, suggesting that double-muscled calves are not predisposed to develop a more precocious or more intense pulmonary hypertension for a given level of hypoxaemia. The significantly smaller normoxic and hypoxic cardiac index and stroke index found in BWB compared with Friesian calves was interpreted as a less efficient cardiac function in double-muscled subjects.
H Amory; F Rollin; D Desmecht; A Linden; P Lekeux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in veterinary science     Volume:  52     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  316-24     Citation Subset:  IM    
Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liège, Brussels, Belgium.
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MeSH Terms
Acute Disease
Anoxia / complications,  etiology,  physiopathology,  veterinary*
Blood Gas Analysis
Blood Pressure
Carbon Dioxide / blood
Cattle Diseases / etiology,  physiopathology*
Heart Rate
Hydrogen-Ion Concentration
Linear Models
Oxygen / blood
Pulmonary Artery / physiology
Pulmonary Wedge Pressure
Stroke Volume
Vascular Resistance
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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