Document Detail

Cardiovascular response to acute hypoxemia in adult rats hypoxemic neonatally.
MedLine Citation:
PMID:  11744036     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of chronic hypoxemia neonatally on the cardiovascular response to acute hypoxemia in adulthood. METHODS: Experiments were conducted on adult rats (82+/-2 days) which had been made chronically hypoxemic (hypobaric hypoxia equivalent to FiO(2)=0.14) during the first ten days of life but raised in room air (Neonatally Hypoxemia) as well as on adult rats never previously hypoxemic (Control). The animals were instrumented with catheters in the right common carotid artery and superior vena cava for measurements of mean systemic arterial pressure (MAP), central venous pressure, heart rate (HR), arterial blood gases, and arterial as well as mixed venous O(2) saturation. Oxygen consumption (VO(2)) was measured allowing calculation of cardiac index (CI), stroke volume index (SVI) and systemic vascular resistance index (SVRI). The rats were made acutely hypoxemic by exposure to FiO(2)=0.10 for 20 min. RESULTS: HR increased and MAP decreased to similar extents in both groups during acute hypoxemia. However, SVI and CI increased significantly (P<0.05) during acute hypoxemia in the Neonatally Hypoxemic group (24+/-6%, 41+/-8%) but respectively decreased and did not change in the Control animals (-13+/-6%, 2+/-6%). SVRI fell significantly more during hypoxemia in the Neonatally Hypoxemic animals than in the Control group (36+/-4% vs. 14+/-5%). CONCLUSIONS: Hypoxemia experienced in early life has long-term effects on the cardiovascular response to acute hypoxemia at maturity. This may have important implications for individuals hypoxemic in early life due to congenital cyanotic heart defects or pulmonary disease secondary to prematurity.
C V Rohlicek; T Matsuoka; C Saiki
Related Documents :
24581676 - Low dietary sodium in diabetes nephropathy.
2587116 - Influence of thromboxane a2 receptor antagonism on pulmonary vasoconstrictor responses.
1884456 - Repolarization inhomogeneities in ventricular myocardium change dynamically with abrupt...
23089926 - Association of the hindiii and s447x polymorphisms in lpl gene with hypertension and ty...
8678256 - Severe hyperventilation and respiratory alkalosis during pressure-support ventilation: ...
7133606 - Local injection of steroids for juvenile hemangiomas which disturb the visual axis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  53     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-05-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  263-70     Citation Subset:  IM    
Department of Pediatrics McGill University & Division of Cardiology Montréal Children's Hospital, 2300 Tupper Street, Montréal, Québec, Canada H3H 1P3.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Newborn
Anoxia / physiopathology*
Blood Pressure
Cardiovascular System / physiopathology*
Heart Rate
Rats, Sprague-Dawley
Stroke Volume
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endothelial dysfunction of coronary resistance vessels in apoE-/- mice involves NO but not prostacyc...
Next Document:  Microvascular correlates of blood pressure, plasma glucose, and insulin resistance in health.