| Cardiovascular and renal function during exercise-induced blood volume expansion in men. | |
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MedLine Citation:
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PMID: 7928889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that reduced baroreflex sensitivity is a direct result of exercise, we measured forearm vascular conductance (FVC) responses to graded lower body negative pressure (LBNP) 2, 20, and 44 h after intense exercise. Eight 4-min bouts of exercise at 85% of maximum oxygen uptake produced 3.5 +/- 0.7 and 3.9 +/- 1.0% blood volume (BV) expansions at 20 and 44 h of recovery, respectively. BV was unchanged from control values 2 h after exercise. The reduction in FVC was significantly less than control values during 30 and 40 mmHg of LBNP at 2 and 20 h of recovery, respectively, whereas heart rate and cardiac stroke volume responses were unchanged. Thus, a reduced FVC response to LBNP preceded BV expansion, demonstrating that exercise itself can elicit an attenuation of baroreflex function. To test the hypothesis that volume sensitivity of renal function is attenuated by intense exercise, we measured cardiovascular variables, plasma hormone concentrations, and renal output. At 20 h of recovery, resting mean arterial blood pressure and cardiac output were increased by 6 +/- 1 mmHg and 0.6 +/- 0.2 l/min, respectively, but resting plasma aldosterone and overnight Na+ excretion rate were unchanged. At 44 h of recovery, plasma aldosterone was decreased by 26 +/- 9% and overnight Na+ excretion rate was increased by 51 +/- 26%. Thus, appropriate endocrine and renal responses to increased BV were delayed until 44 h of recovery. Our findings suggest that a postexercise attenuation of baroreflex function participates in the induction of BV expansion by intense exercise. |
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Authors:
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C M Gillen; T Nishiyasu; G Langhans; C Weseman; G W Mack; E R Nadel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 76 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-11-01 Completed Date: 1994-11-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2602-10 Citation Subset: IM; S |
Affiliation:
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John B. Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Baroreflex / physiology* Blood Volume / physiology* Exercise / physiology* Exercise Test Forearm / blood supply Hemodynamics / physiology* Hormones / blood Humans Kidney / physiology* Kidney Function Tests Lower Body Negative Pressure Male Oxygen Consumption / physiology Regional Blood Flow / physiology Stroke Volume / physiology Supine Position / physiology |
| Grant Support | |
ID/Acronym/Agency:
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GM-07527/GM/NIGMS NIH HHS; HL-20634/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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