Document Detail

Cardiovascular and renal effects of systemic hypoxia in chronically instrumented conscious WKY and SHR rats.
MedLine Citation:
PMID:  9288539     Owner:  NLM     Status:  MEDLINE    
The effects of systemic hypoxia upon cardiovascular and renal function in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) are controversial. We examined the effects of systemic normobaric hypoxia (12.5% O2 in N2 for 4 hours) on arterial blood gases (pO2, pCO2, pH), mean arterial pressure (MAP), heart rate (HR), effective renal blood flow (ERBF), glomerular filtration rate (GFR), urine flow (UMV) and renal sodium excretion (U Na V) in conscious unilaterally nephrectomized WKY (n = 12) and SHR (n = 14) chronically instrumented with an arterial, venous and ureter cannula. In WKY hypoxia caused a reduction in arterial pO2 and pCO2 but no change in MAP and HR. In SHR hypoxia induced similar reductions in arterial blood gases, a small decrease in MAP and no change in HR. In both strains hypoxia caused significant increases in ERBF, GFR and U Na V, but insignificant changes in UMV. The hypoxia-induced natriuresis developed 90-120 min after starting the hypoxia. These data indicate that a 4-hour lasting hypoxia has profound effects on sodium excretion in conscious WKY as well as SHR. Systemic hypoxia did not cause significant changes in arterial blood pressure in both rat strains.
G Habermann; C Huckstorf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  105 Suppl 2     ISSN:  0947-7349     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  26-8     Citation Subset:  IM    
Department of Physiology, University of Rostock.
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MeSH Terms
Anoxia / blood,  physiopathology*
Blood Pressure
Carbon Dioxide / blood
Glomerular Filtration Rate
Heart Rate
Hemodynamics / physiology*
Hydrogen-Ion Concentration
Kidney / physiology,  physiopathology*
Oxygen / blood
Partial Pressure
Rats, Inbred SHR
Rats, Inbred WKY
Renal Circulation
Sodium / urine
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7440-23-5/Sodium; 7782-44-7/Oxygen

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