Document Detail

Cardiovascular and renal disease in the adolescent guinea pig after chronic placental insufficiency.
MedLine Citation:
PMID:  15467552     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine the long-term effects of chronic placental insufficiency on the metabolic state and organ structure in the fetal and adolescent guinea pig. STUDY DESIGN: The maternal uterine artery was ligated at day 28-30 to reduce placental function and restrict fetal growth. Whole body and tissue weights and plasma metabolites were determined at 60 days of gestation and 8 weeks of age; tissue structure was determined at the latter age in restricted and control offspring. RESULTS: Fetal growth restriction increased fibrosis in the heart and kidneys (P < .05), increased aortic wall thickening (P < .01), reduced the number of glomeruli in the kidneys (P < .05), and increased the plasma urea and chloride in adolescent offspring. CONCLUSION: This study demonstrates that diseases in the heart, aorta, and kidneys that result from an adverse prenatal environment are evident at adolescence and may contribute to subsequent adult disease.
Todd A Briscoe; Alexandra E Rehn; Sandra Dieni; Jhodie R Duncan; Mary E Wlodek; Julie A Owens; Sandra M Rees
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  847-55     Citation Subset:  AIM; IM    
Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia.
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MeSH Terms
Adrenal Glands / pathology
Aorta / pathology
Arteries / surgery
Body Weight
Cardiovascular Diseases / etiology*
Chlorides / blood
Chronic Disease
Crown-Rump Length
Fetal Growth Retardation / complications*
Gestational Age
Guinea Pigs
Kidney / pathology
Kidney Diseases / etiology*
Kidney Glomerulus / pathology
Myocardium / pathology
Organ Size
Placental Insufficiency / complications*
Urea / blood
Uterus / blood supply
Reg. No./Substance:
0/Chlorides; 57-13-6/Urea

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