| Cardiovascular and renal actions of C-type natriuretic peptide. | |
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MedLine Citation:
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PMID: 1310235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were performed in two groups of anesthetized dogs (n = 5 per group) to determine the cardiovascular and renal actions of synthetic C-type natriuretic peptide (CNP). Systemic infusion of CNP (group 1; 10 and 50 ng.kg-1.min-1 iv) resulted in marked cardiovascular hemodynamic effects characterized by a decrease in mean arterial pressure, cardiac output, and atrial pressures in association with a decrease in sodium excretion. Bolus administration of CNP (group 2; 5 micrograms/kg iv) to minimize cardiovascular hemodynamic changes resulted in only a transient decrease in arterial pressure. Sodium excretion decreased despite a return of arterial pressure to baseline. These biological responses were associated with increases in plasma guanosine 3',5'-cyclic monophosphate (cGMP) in both groups but with no change in urinary cGMP. With both systemic infusion or bolus administration of CNP, significant increases in plasma aldosterone were observed in association with increases in distal nephron sodium reabsorption. This study demonstrates that CNP exhibits profound systemic hemodynamic actions and is indirectly, or perhaps directly, antinatriuretic. |
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Authors:
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A J Stingo; A L Clavell; L L Aarhus; J C Burnett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 262 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-25 Completed Date: 1992-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H308-12 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Blood Pressure / drug effects Cardiac Output / drug effects Cardiovascular System / drug effects* Cyclic GMP / blood Dogs Glomerular Filtration Rate / drug effects Kidney / drug effects* Kidney Tubules, Proximal / metabolism Male Natriuretic Peptide, C-Type Nerve Tissue Proteins / pharmacology* Renal Circulation / drug effects Sodium / metabolism Vascular Resistance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-07111/HL/NHLBI NIH HHS; HL-36634/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 127869-51-6/Natriuretic Peptide, C-Type; 7440-23-5/Sodium; 7665-99-8/Cyclic GMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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