Document Detail

Cardiovascular reflexes in patients with malignant disease.
MedLine Citation:
PMID:  1592572     Owner:  NLM     Status:  MEDLINE    
Although some authors have reported clinical features of autonomic dysfunction in patients with malignant disease only a few systematic studies have been carried out. We have investigated the autonomic function of 48 patients with carcinoma or lymphoma by testing their cardiovascular reflexes, and compared their results with those of 62 healthy volunteers. Our patients showed a smaller increase in heart rate and a greater fall in blood pressure on standing up, as well as a smaller rise in blood pressure in response to contralateral handgrip. The study group showed a higher percentage of established sympathetic lesion (54.2% vs 27.4%, p: 0.008) and of atypical pattern of global autonomic function impairment (50% vs 24.2%, p: 0.03) than the control group. Our data suggest that patients with malignant disease suffer from a definite autonomic dysfunction.
R Martin; J M Delgado; J M Moltò; J M Vicent; R Manzanares; R Insa; J Matìas-Guiu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  13     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-30     Completed Date:  1992-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Neurological Department, Hospital Virgen de los Lirios, Alcoy, Spain.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Heart Rate / physiology
Hemodynamics / physiology*
Middle Aged
Neoplasms / physiopathology*
Reflex / physiology*
Reflex, Stretch / physiology
Valsalva Maneuver

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