Document Detail

Cardiovascular reflexes evoked by histamine stimulation of the stomach.
MedLine Citation:
PMID:  2012216     Owner:  NLM     Status:  MEDLINE    
This study examined the potential for histamine to cause cardiovascular reflexes when applied to the serosal or mucosal surface of the stomach. Thus, in chloralose-anesthetized cats, histamine was applied to the serosal surface of the stomach in concentrations ranging from 0.5 to 1,000 micrograms/ml. This resulted in graded increases in mean arterial pressure (MAP), maximal left ventricular pressure over time (dP/dt), and heart rate ranging from 9 +/- 4 to 30 +/- 3 mmHg, 450 +/- 103 to 1,710 +/- 610 mmHg/s, and 2 +/- 1 to 13 +/- 4 beats/min, respectively. Histamine stimulation of the gastric serosa evoked a greater pressor response than that observed when the same concentration of histamine (100 micrograms/ml) was applied to the gastric mucosa (43 +/- 7 vs. 13 +/- 3 mmHg, respectively). In six cats, celiac ganglionectomy abolished the previously observed cardiovascular response to histamine stimulation of the serosal surface of the stomach. When the gastric serosa was treated with the H1-receptor antagonist diphenhydramine (1 mg/ml) (n = 5), the cardiovascular response to histamine was abolished. In five other cats, administration of the H2-antagonist ranitidine (1 mg/ml) had no effect on the histamine-induced responses. When indomethacin (2-5 mg/ml), was applied to the serosal surface of the stomach (n = 6), histamine-induced increases in MAP and dP/dt were attenuated. However, application of PGE2 (1 microgram/ml) restored these two responses. These results suggest that histamine stimulates H1-receptors in the gastric wall to cause reflex cardiovascular responses that are dependent, in part, on the local production of prostaglandins.
C L Stebbins; S J Theodossy; J C Longhurst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  260     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-09     Completed Date:  1991-05-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1098-105     Citation Subset:  IM    
Department of Internal Medicine, University of California, Davis 95616.
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular Physiological Phenomena*
Cardiovascular System / drug effects
Dinoprostone / pharmacology
Diphenhydramine / pharmacology
Ganglia, Sympathetic / physiology
Gastric Mucosa / drug effects,  physiology
Heart Rate / drug effects
Heart Ventricles / drug effects
Histamine / pharmacology*
Indomethacin / pharmacology
Ranitidine / pharmacology
Stomach / drug effects*,  physiology
Grant Support
Reg. No./Substance:
363-24-6/Dinoprostone; 51-45-6/Histamine; 53-86-1/Indomethacin; 58-73-1/Diphenhydramine; 66357-35-5/Ranitidine

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