Document Detail

Cardiovascular reactions associated with the use of ketamine and epinephrine in plastic surgery.
MedLine Citation:
PMID:  2417535     Owner:  NLM     Status:  MEDLINE    
Intravenous ketamine dissociation anesthesia combined with epinephrine solution infiltration may provoke serious tachyarrhythmias despite diazepam premedication and the use of minimal doses of both drugs. We use a dose of 0.5 mg of ketamine per kilogram of body weight to induce a short period of amnesia and analgesia, which enables us to infiltrate the operative field with lidocaine and epinephrine solution in a 1:200,000 or 1:400,000 concentration. In about 20% of the patients we encountered significant transient tachycardia and elevation of blood pressure, which required no treatment; however, in 2 of our patients, serious arrhythmias occurred that required drug conversions. Such a problem was not encountered with the use of epinephrine alone in patients without a predisposing condition, nor when ketamine in these small doses was used in other large series.
E B Cabbabe; P M Behbahani
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  15     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1986-02-20     Completed Date:  1986-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Intravenous*
Blood Pressure / drug effects*
Cardiac Complexes, Premature / chemically induced*
Diazepam / therapeutic use
Dose-Response Relationship, Drug
Epinephrine / therapeutic use
Ketamine / adverse effects*
Middle Aged
Surgery, Plastic*
Tachycardia / chemically induced*
Reg. No./Substance:
439-14-5/Diazepam; 51-43-4/Epinephrine; 6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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