| Cardiovascular and pulmonary responses to increased acceleration forces during rest and exercise. | |
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MedLine Citation:
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PMID: 22606865 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The reduced cardiac output (CO) secondary to increased acceleration forces (+Gz) has applicability to daily life and pathophysiology. Increased +Gz and reduced CO affect the lung, resulting in reduced oxygen transport. A variety of studies have examined tolerance to high +Gz. METHODS: The present study examines the effect of +1 to +3 Gz on steady-state cardiopulmonary variables at rest and while exercising at +2 Gz and +3 Gz. This study also looks at the deterioration of steady-state cardiopulmonary variables with sustained increased +Gz and after de-training in eight male centrifuge trained subjects. RESULTS: CO (-1.53 L x min(-1)/+Gz), stroke volume (-30 ml/+Gz, SV), and pulmonary diffusing capacity (-3.42 ml x mmHg(-1)/+Gz, DL(co)) decreased linearly with increased +Gz at rest while heart rate (23 bpm/+Gz, HR), total peripheral resistance (0.0095 TPRU/Gz TPR), mean arterial pressure (13.2 mmHg/+Gz, MAP), and ventilation (4.13 L x min(-1)/+Gz, V(E)) increased linearly. During graded exercise, CO and SV increased less at +2 Gz and +3 Gz while MAP and VE increased more. Failure to endure increased +Gz and the effects of de-training were primarily due to the inability to regulate MAP. DISCUSSION: The incremental increase in increased +Gz from 1 to 3 resulted in increased MAP, which was accomplished by increasing TPR sufficiently so as to offset the reduced CO. The effects of increased +Gz and reduced CO compromised lung function and oxygen transport (-18-30%), thus compromising exercise capacity. The failure to regulate MAP at lower increased +Gz levels resulted in intolerance to higher increased +Gz. |
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Authors:
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David R Pendergast; Albert Olszowka; Leon E Farhi |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Aviation, space, and environmental medicine Volume: 83 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 488-95 Citation Subset: IM; S |
Affiliation:
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Center for Research and Education in Special Environments, Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA. dpenderg@buffalo.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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