Document Detail


Cardiovascular and pulmonary effects of hetastarch plus hypertonic saline solutions during experimental endotoxemia in anesthetized horses.
MedLine Citation:
PMID:  17186860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Small volume resuscitation has been advocated as a beneficial therapy for endotoxemia in horses but this therapy has not been investigated in a prospective manner. The objective of this study was to determine the cardiopulmonary effects of small-volume resuscitation using hypertonic saline solution (HSS) plus Hetastarch (HES) during experimental endotoxemia in anesthetized horses. HYPOTHESIS: Treatment of horses with induced endotoxemia using HES-HSS does not alter the response of various cardiopulmonary indices when compared to treatment with either small- or large-volume isotonic crystalloid solutions. ANIMALS: Eighteen healthy horses were randomly assigned to 1 of 3 groups. Anesthesia was maintained with halothane. Endotoxemia was induced by administering 50 microg/kg of Escherichia coli endotoxin IV. The horses were treated over 30 minutes with 15 mL/kg of balanced polyionic crystalloid solution (control), 60 mL/kg of balanced polyionic crystalloid solution (ISO), or 5 mL/kg of HSS followed by 10 mL/kg of HES (HSS-HES). METHODS: Prospective randomized trial. RESULTS: Cardiac output (CO) after endotoxin infusion increased significantly (P < .05) from baseline in all groups, whereas mean central venous pressure increased significantly (P < .05) in the ISO group only. Mean pulmonary artery pressure increased from baseline (P < .05) in horses treated with isotonic fluids and HSS-HES. There was no effect of treatment with HSS-HES on CO, systemic vascular resistance (SVR), mean arterial pressure, blood lactate concentrations, or arterial oxygenation. CONCLUSIONS AND CLINICAL IMPORTANCE: The use of HSS-HES failed to ameliorate the deleterious hemodynamic responses associated with endotoxemia in horses. The clinical value of this treatment in horses with endotoxemia remains unconfirmed.
Authors:
Lucas G Pantaleon; Martin O Furr; Harold C McKenzie; Lydia Donaldson
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  20     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1422-8     Citation Subset:  IM    
Affiliation:
Marion duPont Scott Equine Medical Center, Virginia/ Maryland Regional College of Veterinary Medicine, Leesburg, VA, USA. lucaspantaleon@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium
Anesthesia / veterinary
Animals
Blood Gas Analysis / veterinary
Blood Pressure
Blood Volume
Cardiac Output / drug effects
Endotoxemia / therapy,  veterinary*
Hemodilution / veterinary
Hetastarch / pharmacology*
Horse Diseases / drug therapy*
Horses
Plasma Substitutes / pharmacology*
Prospective Studies
Saline Solution, Hypertonic / pharmacology*
Shock, Septic / therapy,  veterinary
Treatment Outcome
Vascular Resistance
Chemical
Reg. No./Substance:
0/Plasma Substitutes; 0/Saline Solution, Hypertonic; 9005-27-0/Hetastarch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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