| Cardiovascular and pulmonary effects of hetastarch plus hypertonic saline solutions during experimental endotoxemia in anesthetized horses. | |
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MedLine Citation:
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PMID: 17186860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Small volume resuscitation has been advocated as a beneficial therapy for endotoxemia in horses but this therapy has not been investigated in a prospective manner. The objective of this study was to determine the cardiopulmonary effects of small-volume resuscitation using hypertonic saline solution (HSS) plus Hetastarch (HES) during experimental endotoxemia in anesthetized horses. HYPOTHESIS: Treatment of horses with induced endotoxemia using HES-HSS does not alter the response of various cardiopulmonary indices when compared to treatment with either small- or large-volume isotonic crystalloid solutions. ANIMALS: Eighteen healthy horses were randomly assigned to 1 of 3 groups. Anesthesia was maintained with halothane. Endotoxemia was induced by administering 50 microg/kg of Escherichia coli endotoxin IV. The horses were treated over 30 minutes with 15 mL/kg of balanced polyionic crystalloid solution (control), 60 mL/kg of balanced polyionic crystalloid solution (ISO), or 5 mL/kg of HSS followed by 10 mL/kg of HES (HSS-HES). METHODS: Prospective randomized trial. RESULTS: Cardiac output (CO) after endotoxin infusion increased significantly (P < .05) from baseline in all groups, whereas mean central venous pressure increased significantly (P < .05) in the ISO group only. Mean pulmonary artery pressure increased from baseline (P < .05) in horses treated with isotonic fluids and HSS-HES. There was no effect of treatment with HSS-HES on CO, systemic vascular resistance (SVR), mean arterial pressure, blood lactate concentrations, or arterial oxygenation. CONCLUSIONS AND CLINICAL IMPORTANCE: The use of HSS-HES failed to ameliorate the deleterious hemodynamic responses associated with endotoxemia in horses. The clinical value of this treatment in horses with endotoxemia remains unconfirmed. |
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Authors:
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Lucas G Pantaleon; Martin O Furr; Harold C McKenzie; Lydia Donaldson |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 20 ISSN: 0891-6640 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 1422-8 Citation Subset: IM |
Affiliation:
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Marion duPont Scott Equine Medical Center, Virginia/ Maryland Regional College of Veterinary Medicine, Leesburg, VA, USA. lucaspantaleon@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Anesthesia / veterinary Animals Blood Gas Analysis / veterinary Blood Pressure Blood Volume Cardiac Output / drug effects Endotoxemia / therapy, veterinary* Hemodilution / veterinary Hetastarch / pharmacology* Horse Diseases / drug therapy* Horses Plasma Substitutes / pharmacology* Prospective Studies Saline Solution, Hypertonic / pharmacology* Shock, Septic / therapy, veterinary Treatment Outcome Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/Plasma Substitutes; 0/Saline Solution, Hypertonic; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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