Document Detail


Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid.
MedLine Citation:
PMID:  12939515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is widely accepted that n-3 polyunsaturated fatty acids (PUFAs) rich in fish oils protect against several types of cardiovascular diseases such as myocardial infarction, arrhythmia, atherosclerosis, or hypertension. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be the active biological components of these effects. Although the precise cellular and molecular mechanisms underlying the beneficial effects are still uncertain, the protective effects of n-3 PUFAs are attributable to their direct effects on vascular smooth muscle cell (VSMC) functions. These n-3 PUFAs activate K(+)(ATP) channels and inhibit certain types of Ca(2+) channels, probably via at least 2 distinct mechanisms. N-3 PUFAs favorably alter the eicosanoid profile and regulate cytokine-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 via mechanisms involving modulation of signaling transduction events. N-3 PUFAs also modulate VSMC proliferation, migration, and apoptosis. These recent data suggest that modulation of these VSMC functions contribute to the beneficial effects of n-3 PUFAs on various cardiovascular disorders. Furthermore, recent studies strongly suggest that DHA has more potent and beneficial effects than EPA. However, many questions about the cellular and molecular mechanisms still remain to be answered.
Authors:
Masahiko Hirafuji; Takuji Machida; Naoya Hamaue; Masaru Minami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  92     ISSN:  1347-8613     ISO Abbreviation:  J. Pharmacol. Sci.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-26     Completed Date:  2004-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  308-16     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan. hirafuji@hoku-iryo-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiotonic Agents / pharmacology,  therapeutic use*
Cardiovascular Diseases / metabolism,  prevention & control*
Cardiovascular System / drug effects*,  metabolism
Docosahexaenoic Acids / pharmacology,  therapeutic use*
Fatty Acids, Omega-3 / pharmacology,  therapeutic use
Humans
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids

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