Document Detail


Cardiovascular protective effects of on-line hemodiafiltration: comparison with conventional hemodialysis.
MedLine Citation:
PMID:  22458399     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Atherosclerotic complications have a significant effect on mortality in patients undergoing hemodialysis (HD) therapy. However, anti-atherosclerotic and cardioprotective effects of on-line hemodiafiltration (HDF) remain to be elucidated. We prospectively compared the anti-atherosclerotic and cardioprotective effects in two randomly divided groups, i.e. on-line HDF group (n = 13) and conventional HD group (n = 9) for 1 year. Surrogate markers were brachial-ankle pulse wave velocity (baPWV), intima-media thickness (IMT) of carotid artery as an atherosclerosis marker, and cardiac functional surrogate markers included left ventricular mass index (LVMI), ejection fraction (EF), and LV diastolic capacity represented as E/A and deceleration time (DT). LVMI in on-line HDF patients showed significant regression after 1 year of treatment (131.9 ± 25.8 to 116.5 ± 24.7 g/m(2) , P = 0.03), while LVMI in HD patients did not show any significant change (148.0 ± 47.1 to 142.3 ± 35.5 g/m(2) ). Levels of baPWV in HD patients showed a significant increase (11.4%) from basal levels, while on-line HDF groups showed no significant increase. Furthermore, HD patients showed significant worsening of LV diastolic capacity (E/A: from 0.87 ± 0.12 to 0.79 ± 0.08, P = 0.03), while it was not shown in on-line HDF patients. Ejection fraction and IMT did not show any significant change in both groups. Serum albumin, C-reactive protein, β2 microglobulin, blood pressure, and anti-hypertensive drug use did not change in both groups. On-line HDF showed a significant improvement in LVMI and prevented a significant worsening of baPWV or LV diastolic capacity compared with patients on conventional HD therapy.
Authors:
Takayasu Ohtake; Machiko Oka; Kunihiro Ishioka; Kenjiro Honda; Yasuhiro Mochida; Kyoko Maesato; Hidekazu Moriya; Sumi Hidaka; Shuzo Kobayashi
Related Documents :
2541809 - Abnormalities in the response of plasma arginine vasopressin during hypertonic saline i...
9840319 - Study on nutritional status of maintenance hemodialysis patients.
107789 - Nasogastric hyperalimentation through a polyethylene catheter: an alternative to centra...
3258799 - Nutritional status of patients on hemodialysis and peritoneal dialysis.
6766049 - Nutritional benefits of immediate postoperative jejunal feeding of an elemental diet.
12415549 - Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol ...
773419 - Radiation-induced immune changes in patients with cancer of the cervix.
23327059 - Overexpression of c-met in cervical intraepithelial neoplasia.
19344979 - Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in ...
Publication Detail:
Type:  Journal Article     Date:  2012-02-02
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  16     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  181-8     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis.
Affiliation:
Department of Nephrology, Immunology, and Vascular Medicine, Shonan Kamakura General Hospital, Kamakura, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of peripheral blood mononuclear cells morphology on vascular calcification in uremic patient...
Next Document:  Low Density Lipoprotein Apheresis Ameliorates Interferon-? Production in Patients With Nephrotic Syn...