| Cardiovascular protective effects of on-line hemodiafiltration: comparison with conventional hemodialysis. | |
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MedLine Citation:
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PMID: 22458399 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Atherosclerotic complications have a significant effect on mortality in patients undergoing hemodialysis (HD) therapy. However, anti-atherosclerotic and cardioprotective effects of on-line hemodiafiltration (HDF) remain to be elucidated. We prospectively compared the anti-atherosclerotic and cardioprotective effects in two randomly divided groups, i.e. on-line HDF group (n = 13) and conventional HD group (n = 9) for 1 year. Surrogate markers were brachial-ankle pulse wave velocity (baPWV), intima-media thickness (IMT) of carotid artery as an atherosclerosis marker, and cardiac functional surrogate markers included left ventricular mass index (LVMI), ejection fraction (EF), and LV diastolic capacity represented as E/A and deceleration time (DT). LVMI in on-line HDF patients showed significant regression after 1 year of treatment (131.9 ± 25.8 to 116.5 ± 24.7 g/m(2) , P = 0.03), while LVMI in HD patients did not show any significant change (148.0 ± 47.1 to 142.3 ± 35.5 g/m(2) ). Levels of baPWV in HD patients showed a significant increase (11.4%) from basal levels, while on-line HDF groups showed no significant increase. Furthermore, HD patients showed significant worsening of LV diastolic capacity (E/A: from 0.87 ± 0.12 to 0.79 ± 0.08, P = 0.03), while it was not shown in on-line HDF patients. Ejection fraction and IMT did not show any significant change in both groups. Serum albumin, C-reactive protein, β2 microglobulin, blood pressure, and anti-hypertensive drug use did not change in both groups. On-line HDF showed a significant improvement in LVMI and prevented a significant worsening of baPWV or LV diastolic capacity compared with patients on conventional HD therapy. |
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Authors:
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Takayasu Ohtake; Machiko Oka; Kunihiro Ishioka; Kenjiro Honda; Yasuhiro Mochida; Kyoko Maesato; Hidekazu Moriya; Sumi Hidaka; Shuzo Kobayashi |
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Publication Detail:
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Type: Journal Article Date: 2012-02-02 |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 16 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 181-8 Citation Subset: IM |
Copyright Information:
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© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis. |
Affiliation:
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Department of Nephrology, Immunology, and Vascular Medicine, Shonan Kamakura General Hospital, Kamakura, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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