| Cardiovascular prognostic value of ambulatory blood pressure monitoring in a Portuguese hypertensive population followed up for 8.2 years. | |
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MedLine Citation:
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PMID: 20616705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: We investigated the cardiovascular (CV) prognostic value of 24-h ambulatory blood pressure (ABP) and blood pressure (BP) during the six 4-h periods of the 24-h ABP length in a cohort of 1200 Portuguese hypertensive patients (aged 51±12 years) without earlier CV events. METHOD: The presence of CV events were followed for 9.833 patient years and analyzed using a cox hazard model. RESULTS: During the 15.2 (mean 8.2) years follow-up, there were 152 CV events (11% fatal) including 79 strokes and 52 coronary events. After adjustment for risk factors and office BP (OBP), a 1-standard deviation increment of 24-h, daytime and night-time systolic BP (SBP) significantly predicted any CV event with hazard ratios (HR) 1.41, 1.33 and 1.57, respectively, and stroke with HR 1.67, 1.58, 1.67, respectively (all P<0.01), but not coronary events. Prognostic significance of these SBP values and of night-time ABP persisted after adjustment for diastolic BP and daytime ABP, respectively, whereas the opposite did not occur. SBP night-time fall (%) inversely predicted total CV events after adjustment for diastolic BP night-time fall. Among all six 4-h periods of 24-h, increment of SBP during the first 4 h of night-time was the most powerful predictor of any CV event (HR 1.64) and stroke (HR 2.02) (both P<0.01) even after adjustment for daytime and 24-h BP. CONCLUSION: In predicting CV events and stroke, ABP is superior to office BP, ABP systolic is superior to ABP diastolic, and night-time BP is superior to daytime BP particularly during the first 4 h of sleep. |
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Authors:
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José Mesquita-Bastos; Susana Bertoquini; Jorge Polónia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure monitoring Volume: 15 ISSN: 1473-5725 ISO Abbreviation: Blood Press Monit Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606438 Medline TA: Blood Press Monit Country: England |
Other Details:
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Languages: eng Pagination: 240-6 Citation Subset: IM |
Affiliation:
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Escola Superior de Saúde da Universidade de Aveiro, EPE, Aveiro, Portugal. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory* Cardiovascular Diseases / etiology* Circadian Rhythm / physiology Female Follow-Up Studies Heart Rate Humans Hypertension / complications*, physiopathology Male Middle Aged Office Visits Portugal Prognosis Prospective Studies |
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