Document Detail


Cardiovascular profile of oxodipine, a novel dihydropyridine calcium channel blocker, in anesthetized open-chest dogs: a comparison with nitrendipine.
MedLine Citation:
PMID:  1816765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiovascular effects of oxodipine, a new dihydropyridine calcium channel blocker, were studied after i.v. administration to chloralose-anesthetized dogs, and compared with those of nitrendipine. Nitrendipine produced more marked decreases than oxodipine in both systolic and diastolic blood pressure and in total peripheral resistance. No significant modification of heart rate was observed. Oxodipine decreased cardiac contractility, whereas nitrendipine increased it. This difference originated in reflex modifications, since both drugs, administered at doses of 30 and 60 micrograms/kg, decreased cardiac contractility during studies performed after cardiac autonomic blockade. Under these conditions, nitrendipine decreased heart rate, whereas oxodipine had no effect. The two drugs showed comparable effects on coronary and femoral vascular resistance. However, oxodipine caused a very marked persistent decrease of vertebral vascular resistance. On this local circulation, nitrendipine had a weak effect. The results from the present study indicate that oxodipine predominantly increases vertebral blood flow with a concomitant hypertension which is more moderate than after nitrendipine.
Authors:
A Alloui; J M Talmant; P Duchêne-Marullaz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  313     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1991 Sep-Oct
Date Detail:
Created Date:  1992-06-29     Completed Date:  1992-06-29     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  63-75     Citation Subset:  IM    
Affiliation:
INSERM U195, Faculty of Medicine, Clermont-Ferrand, France.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Anesthesia
Animals
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology*
Dihydropyridines / pharmacology*
Dogs
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Male
N-Methylscopolamine
Nitrendipine / pharmacology*
Propranolol / pharmacology
Regional Blood Flow / drug effects
Scopolamine Derivatives / pharmacology
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Dihydropyridines; 0/Scopolamine Derivatives; 13265-10-6/N-Methylscopolamine; 39562-70-4/Nitrendipine; 525-66-6/Propranolol; 90729-41-2/oxodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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