Document Detail

Cardiovascular profile of the canine torsades de pointes arrhythmia model assessed by echocardiographic and haemodynamic methods.
MedLine Citation:
PMID:  17577314     Owner:  NLM     Status:  MEDLINE    
Chronic atrioventricular block dogs have been established as an in vivo model of drug-induced torsades de pointes arrhythmias. We compared the cardiovascular profile of the canine model with that of sham-operated animals using echocardiographic and haemodynamic methods. In the echocardiographic study, the larger diameters of the left atria, inferior vena cava and left ventricle in end-diastole in addition to greater fractional shortening, end-diastolic volume, stroke volume and ejection fraction were more often detected in the chronic atrioventricular block dogs than in the sham-operated animals. During haemodynamic examination, lower cardiac output and higher pulmonary capillary wedge pressure were detected in chronic atrioventricular block dogs more than in sham-operated animals; however, these changes were within the physiological limits, and the results suggest that the chronic atrioventricular block dogs have a pathophysiological profile of chronic compensated heart failure.
Akira Takahara; Atsushi Sugiyama; Yoshioki Satoh; Hiroshi Iwasaki; Yuji Nakamura; Keitaro Hashimoto
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  101     ISSN:  1742-7835     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-19     Completed Date:  2007-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
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MeSH Terms
Blood Pressure
Cardiac Output
Disease Models, Animal
Heart / physiopathology*
Heart Block / physiopathology*
Heart Rate
Stroke Volume
Torsades de Pointes / physiopathology*

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